{"id":"W1984671864","doi":"10.1007/s00239-013-9589-5","title":"Molecular Evolutionary Analysis of Vertebrate Transducins: A Role for Amino Acid Variation in Photoreceptor Deactivation","year":2013,"lang":"en","type":"article","venue":"Journal of Molecular Evolution","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Transducin; Biology; Vertebrate; Visual phototransduction; Evolutionary biology; Heterotrimeric G protein; Phylogenetics; Molecular evolution; Phylogenetic tree; Negative selection; Rhodopsin; Genetics; Biophysics; G protein; Retinal; Retina; Genome; Neuroscience; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003224821,0.0001402085,0.0002780169,0.0004900845,0.00002985673,0.00001375332,0.000145697,0.0002055713,0.00002538961],"category_scores_gemma":[0.0001842966,0.0001400424,0.0003150404,0.0005262936,0.00003175389,0.00003780192,0.00001687315,0.000106252,0.00000149608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009978627,"about_ca_system_score_gemma":0.000165485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006074193,"about_ca_topic_score_gemma":0.00001594297,"domain_scores_codex":[0.9986503,0.0001019098,0.0005956361,0.0001948724,0.0002787237,0.0001786168],"domain_scores_gemma":[0.9988309,0.00001260603,0.0004607021,0.0001467913,0.0004905547,0.00005841752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002215257,0.0001398171,0.006847844,0.00001866042,0.0004485026,0.000001101964,0.0001013078,0.004919766,0.9862472,0.0001986096,0.0001236849,0.0007319322],"study_design_scores_gemma":[0.001691961,0.0005836019,0.3473529,0.00004200594,0.0004808184,0.000007773679,0.0002101087,0.01161589,0.6355261,0.001944956,0.0002906054,0.0002532714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8551562,0.001109476,0.1431556,0.0001236209,0.00007875577,0.000284397,0.000006756076,0.000002527159,0.00008258899],"genre_scores_gemma":[0.9949359,0.00006314597,0.004721689,0.00007252206,0.00003125231,0.00003425868,0.0001133463,0.00001491897,0.00001295823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3507212,"threshold_uncertainty_score":0.5710764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003756588531925265,"score_gpt":0.211098925936705,"score_spread":0.2073423374047798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}