{"id":"W1984684945","doi":"10.1038/sj.npp.1301092","title":"Involvement of the Endocannabinoid System in the Ability of Long-Term Tricyclic Antidepressant Treatment to Suppress Stress-Induced Activation of the Hypothalamic–Pituitary–Adrenal Axis","year":2006,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute on Drug Abuse; Natural Sciences and Engineering Research Council of Canada; Michael Smith Health Research BC; National Alliance for Research on Schizophrenia and Depression","keywords":"Desipramine; AM251; Endocrinology; Internal medicine; Endocannabinoid system; Corticosterone; Tricyclic antidepressant; Hypothalamus; Cannabinoid receptor; Cannabinoid; Antidepressant; Tricyclic; Hippocampus; Chemistry; Pharmacology; Receptor; Medicine; Antagonist; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001256132,0.0001728774,0.0002551166,0.0001093594,0.0001842736,0.000249504,0.0001562712,0.0002455804,0.001631571],"category_scores_gemma":[0.0002331461,0.0001111225,0.0001539317,0.00008546656,0.0002327847,0.0001572631,0.0001174172,0.000423579,0.0001604737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004300177,"about_ca_system_score_gemma":0.0005170851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00255895,"about_ca_topic_score_gemma":0.008483951,"domain_scores_codex":[0.9999485,0.00001265426,0.00000597586,0.000005520951,0.000009352209,0.00001807612],"domain_scores_gemma":[0.9998841,0.00002754347,0.00003171949,0.00001665761,0.0000136247,0.00002638272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00861966,0.0004506951,0.00629315,0.0003215432,0.0001794966,0.0006259338,0.0001295565,0.0002665912,0.9358583,0.0006761213,0.0003025392,0.04627641],"study_design_scores_gemma":[0.0013424,0.008948259,0.655983,0.0001013085,0.0004287219,0.003187685,0.0003404443,0.00221038,0.317913,0.001053018,0.008435557,0.00005615051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992059,0.005140572,0.000325229,0.0002452068,0.0000304563,0.00002570483,0.0001819095,0.00001044134,0.001981505],"genre_scores_gemma":[0.9968569,0.001737499,0.0002332309,0.00006831735,0.0000129132,0.00001179246,0.0001278869,0.000001774672,0.0009496225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00255895,"threshold_uncertainty_score":0.005458117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02242354788402152,"score_gpt":0.3113768368413832,"score_spread":0.2889532889573617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}