{"id":"W1984698740","doi":"10.1089/10430340152528165","title":"A Novel Parasite-Derived Suicide Gene for Cancer Gene Therapy with Specificity for Lung Cancer Cells","year":2001,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"National Cancer Institute","keywords":"Suicide gene; Prodrug; Cancer research; Cytotoxicity; Lung cancer; Biology; Allopurinol; Cytotoxic T cell; Cytosine deaminase; Genetic enhancement; Pharmacology; Molecular biology; Chemistry; Biochemistry; Gene; Medicine; In vitro; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001607353,0.0002818739,0.0002673936,0.0001877607,0.0001289279,0.0002795449,0.0002258746,0.0003831767,0.0004656137],"category_scores_gemma":[0.0001506187,0.0001156955,0.000210796,0.0001497007,0.0002397687,0.0002125831,0.0002477095,0.0005530453,0.0002943565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002853944,"about_ca_system_score_gemma":0.0001908283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003413572,"about_ca_topic_score_gemma":0.0004868999,"domain_scores_codex":[0.9998647,0.00002592055,0.000009208034,0.00002853151,0.0000511894,0.00002050735],"domain_scores_gemma":[0.9999424,0.00001405195,0.00001431935,0.000008025277,0.00001024969,0.00001094691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002374562,0.00001634047,0.00008418786,0.00004271763,0.000003941877,0.00007467855,0.00001515475,0.00008340821,0.9963027,0.0003439142,0.00004053846,0.002968627],"study_design_scores_gemma":[0.0000285636,0.0005029226,0.0007299304,0.00000744699,0.00003339117,0.001386364,0.0000126026,0.001663913,0.9881966,0.00007036814,0.007360459,0.000007536476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8991933,0.005906137,0.09068327,0.0003552131,0.00009730462,0.0002767067,0.0002799078,0.0004117181,0.00279637],"genre_scores_gemma":[0.9546799,0.002509619,0.0384455,0.00007121659,0.00001514775,0.0001033459,0.0004378705,0.00004965649,0.003687698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004656137,"threshold_uncertainty_score":0.002070665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05395230012644987,"score_gpt":0.3531918853659262,"score_spread":0.2992395852394763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}