{"id":"W1984703406","doi":"10.1021/jo8026565","title":"Establishment of Broadly Applicable Reaction Conditions for the Palladium-Catalyzed Direct Arylation of Heteroatom-Containing Aromatic Compounds","year":2009,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":591,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Amgen","keywords":"Chemistry; Palladium; Pivalic acid; Aryl; Heteroatom; Catalysis; Stoichiometry; Halide; Reaction conditions; Organic chemistry; Coupling reaction; Combinatorial chemistry; Ring (chemistry)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001080558,0.0001580082,0.0003683954,0.00003538649,0.0001452386,0.00002399593,0.0003716732,0.00009682777,0.0004976604],"category_scores_gemma":[0.000503058,0.0001110466,0.0001888185,0.0002519283,0.0001032286,0.0001337802,0.00002997753,0.0002238672,0.000001001561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001932426,"about_ca_system_score_gemma":0.0001744895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001242806,"about_ca_topic_score_gemma":0.000001810188,"domain_scores_codex":[0.9983811,0.00002989513,0.0009001844,0.0001176653,0.0004169665,0.0001541908],"domain_scores_gemma":[0.996501,0.001241204,0.001454801,0.0004403951,0.0003021804,0.00006037305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002369617,0.0001235796,0.0001559153,0.0001447852,0.0001760268,3.979693e-7,0.0002960543,0.0004404139,0.9972827,0.00001458461,0.0006190402,0.0005095306],"study_design_scores_gemma":[0.001251206,0.00004398986,0.0009718671,0.0001555444,0.0004586054,0.0002159754,0.0009139878,0.0009356063,0.9930851,0.00120216,0.0006500728,0.0001158192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781342,0.0004950205,0.01699142,0.0007129644,0.0001248406,0.0002008992,0.00004931865,0.00002838673,0.003262936],"genre_scores_gemma":[0.9986017,0.00007232172,0.0006313875,0.00003434068,0.0002391484,0.000005870319,0.00007908828,0.00001990004,0.0003162144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02046751,"threshold_uncertainty_score":0.5449032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01788781554683976,"score_gpt":0.2746175723356369,"score_spread":0.2567297567887972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}