{"id":"W1984705614","doi":"10.1124/mol.105.021931","title":"Tamoxifen and Raloxifene Differ in Their Functional Interactions with Aspartate 351 of Estrogen Receptor α","year":2006,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; McGill University; Institute for Research in Immunology and Cancer","funders":"","keywords":"Raloxifene; Tamoxifen; Chemistry; Estrogen receptor; Selective estrogen receptor modulator; Antiestrogen; Stereochemistry; Side chain; Estrogen; Tertiary amine; Agonist; Antagonist; Pharmacology; Receptor; Biochemistry; Internal medicine; Endocrinology; Biology; Medicine; Organic chemistry; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007993225,0.0001668169,0.0001796479,0.00008375402,0.00003629415,0.000006287659,0.00007541086,0.0001196077,0.00005263695],"category_scores_gemma":[0.00000539216,0.0001365367,0.00005870529,0.0001130828,0.0001402629,0.000005044859,0.00005904067,0.0001579724,0.000005013575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001387131,"about_ca_system_score_gemma":0.00004598871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003325018,"about_ca_topic_score_gemma":0.00000896516,"domain_scores_codex":[0.9990967,0.0001238482,0.0001940655,0.0002876725,0.00007101403,0.0002267002],"domain_scores_gemma":[0.9996753,0.00001905636,0.00008081402,0.0001186974,0.00004763385,0.00005844923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004161405,0.0001617549,0.004915255,0.00001182587,0.00013655,0.00002559663,0.00001629286,0.0006238892,0.9915662,0.00009197614,0.001722742,0.0003117415],"study_design_scores_gemma":[0.001712,0.0003384548,0.004448021,0.000009243729,0.00004898454,0.00007442487,0.00001004056,0.0001445808,0.9886007,0.00006308997,0.004397923,0.0001525615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964871,0.001493599,0.0006957765,0.0002473184,0.0001921674,0.0002240259,0.00001589824,0.00001049168,0.0006336512],"genre_scores_gemma":[0.9988021,0.00009781885,0.0003219379,0.0001843591,0.0001136446,0.000054901,0.0001733454,0.00002477113,0.0002271831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00296556,"threshold_uncertainty_score":0.5567804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003808025171247728,"score_gpt":0.2194979069808477,"score_spread":0.2156898818096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}