{"id":"W1984707191","doi":"10.1016/j.jmb.2012.11.037","title":"CDR-H3 Diversity Is Not Required for Antigen Recognition by Synthetic Antibodies","year":2012,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":164,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; National Human Genome Research Institute; Canadian Institutes of Health Research","keywords":"Antibody Repertoire; Complementarity determining region; Antibody; Antigen; Biology; Primary and secondary antibodies; Repertoire; Genetics; Computational biology; Immunoglobulin light chain","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002897258,0.000239139,0.0002550436,0.0001806177,0.0002083194,0.0005962404,0.0003498998,0.0003417865,0.002280887],"category_scores_gemma":[0.0005599278,0.0002680795,0.0002579176,0.0001554415,0.0003026071,0.0002422615,0.0002841417,0.0008571355,0.0006130108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003502487,"about_ca_system_score_gemma":0.000312792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005106625,"about_ca_topic_score_gemma":0.0007948622,"domain_scores_codex":[0.9996681,0.00007756948,0.00002212983,0.00005059571,0.00008646554,0.00009509151],"domain_scores_gemma":[0.9992515,0.0002998465,0.000127408,0.0001101718,0.00006759268,0.0001434056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001182624,0.00001737215,0.0003797529,0.00001256543,0.000007042424,0.00006256848,0.000007291882,0.00007047084,0.9986123,0.0001016249,0.00002754474,0.0005832302],"study_design_scores_gemma":[0.00004193881,0.000214352,0.005579651,0.000006192957,0.000017703,0.0006504518,0.00003233855,0.001351438,0.9903708,0.000117368,0.00161056,0.00000729187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960256,0.0001835535,0.002122349,0.00003721811,0.00001888147,0.000011929,0.0001182618,0.00003856042,0.001443632],"genre_scores_gemma":[0.9983585,0.00004459334,0.0008126072,0.00004943958,0.00000619215,0.000006711343,0.0002796747,0.00002041367,0.0004217315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002280887,"threshold_uncertainty_score":0.007630348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05923709257145068,"score_gpt":0.3547683442076544,"score_spread":0.2955312516362037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}