{"id":"W1984719849","doi":"10.1002/glia.20576","title":"Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells","year":2007,"lang":"en","type":"article","venue":"Glia","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Biology; Remyelination; Downregulation and upregulation; Fingolimod; Cell biology; Sphingosine-1-phosphate receptor; Receptor; Sphingosine-1-phosphate; Platelet-derived growth factor receptor; Phosphorylation; Neuroscience; Platelet-derived growth factor; Progenitor cell; Neuregulin; Growth factor; Signal transduction; Sphingosine; Immunology; Multiple sclerosis; Stem cell; Myelin; Biochemistry; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001130122,0.0003328435,0.0002030361,0.0002279596,0.000124842,0.0001758581,0.0001504134,0.0002109052,0.0008335861],"category_scores_gemma":[0.00009374921,0.0001023942,0.0002021661,0.0001316294,0.0001953028,0.0001421457,0.0001216918,0.0002990932,0.0002859901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002570586,"about_ca_system_score_gemma":0.0002055497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001508862,"about_ca_topic_score_gemma":0.001878382,"domain_scores_codex":[0.9998808,0.00002042278,0.0000122111,0.00001850066,0.00002947779,0.00003864656],"domain_scores_gemma":[0.999935,0.00001090844,0.00001981496,0.000006976128,0.000008222247,0.0000190173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001403061,0.00001040281,0.00008235619,0.00001739406,0.000002217152,0.00006304888,0.00001325507,0.00002178071,0.9990602,0.00003913898,0.00001085108,0.0005390443],"study_design_scores_gemma":[0.00001107632,0.0003005257,0.003969341,0.000002317426,0.00001355911,0.0001163613,0.00003218976,0.0001428296,0.9947709,0.00001855277,0.0006195734,0.00000288201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984105,0.0007072784,0.000248737,0.0000242351,0.000006185059,0.000003730657,0.0001788468,0.00001558322,0.0004048852],"genre_scores_gemma":[0.9968277,0.0008248184,0.0004737749,0.00002179258,0.000003728097,0.00001700732,0.0003620572,0.000008229678,0.00146092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001508862,"threshold_uncertainty_score":0.003000081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0127059665371102,"score_gpt":0.2408586233400283,"score_spread":0.2281526568029181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}