{"id":"W1984805380","doi":"10.1016/j.vascn.2004.03.001","title":"Delivery of mevalonate to murine extrahepatic tissues via mini-osmotic pumps","year":2004,"lang":"en","type":"article","venue":"Journal of Pharmacological and Toxicological Methods","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"U.S. Army Medical Research Acquisition Activity; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"HMG-CoA reductase; Mevalonate pathway; Reductase; Hydroxymethylglutaryl-CoA reductase; Cholesterol; Coenzyme A; Mevalonic acid; Internal medicine; Endocrinology; Metabolism; Mammary gland; Enzyme; Endogeny; Biology; Chemistry; Biochemistry; Cancer; Medicine; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006073294,0.000957506,0.0005644595,0.0006683405,0.0004109874,0.0007268507,0.0005753836,0.0007855417,0.001411646],"category_scores_gemma":[0.0002133976,0.0004682828,0.0007068474,0.0003274825,0.0006651047,0.0007815377,0.0004400818,0.001519759,0.0005014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006296755,"about_ca_system_score_gemma":0.000565505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009187813,"about_ca_topic_score_gemma":0.001240001,"domain_scores_codex":[0.9995379,0.00007100151,0.00004793594,0.0001176657,0.000100309,0.0001251367],"domain_scores_gemma":[0.9997117,0.00005938581,0.0001009548,0.00004887898,0.00002728684,0.00005182717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005597868,0.00003630005,0.00007762844,0.00009060766,0.00001666152,0.00005420672,0.00005087697,0.0001901994,0.9958398,0.0005932241,0.000106761,0.002384026],"study_design_scores_gemma":[0.00002864728,0.0002528893,0.0001883318,0.000005820408,0.00002287014,0.00005261253,0.00001636417,0.0003340942,0.9970289,0.00004817129,0.002015582,0.000005811583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9226598,0.007845606,0.05808589,0.001033151,0.0007392939,0.0006606399,0.002924899,0.001193941,0.004856759],"genre_scores_gemma":[0.9485315,0.003920787,0.03548512,0.0001632012,0.0001193967,0.0005129972,0.001215878,0.0001708058,0.009880244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001411646,"threshold_uncertainty_score":0.004722416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03426351999544428,"score_gpt":0.3823138136213617,"score_spread":0.3480502936259174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}