{"id":"W1984844116","doi":"10.1006/jmbi.2001.4450","title":"Structure and functionality of a designed p53 dimer11Edited by P. E. Wright","year":2001,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute","keywords":"Transactivation; Tetramer; Mutant; Chemistry; Wild type; Mutation; Oligomer; Denaturation (fissile materials); Cell biology; Biochemistry; Biology; Biophysics; Gene; Transcription factor; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002185672,0.0001345426,0.0004253026,0.0001556545,0.00002488052,0.000003918521,0.00007589624,0.0002379002,0.0001949828],"category_scores_gemma":[0.0001820728,0.0001023914,0.0001415916,0.0002022371,0.0001590201,0.00002748642,0.00002669231,0.0003132099,0.000001017793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005079857,"about_ca_system_score_gemma":0.0001419546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001574528,"about_ca_topic_score_gemma":0.00000206328,"domain_scores_codex":[0.998895,0.0001404723,0.0004554866,0.0001535701,0.0001877257,0.0001676788],"domain_scores_gemma":[0.9989657,0.00004440942,0.0003773259,0.0001665852,0.0003000351,0.0001459009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006581757,0.00007479683,0.003175216,0.00002204426,0.0003203925,0.0001872904,0.00002439972,0.00001031173,0.9901199,0.0001758388,0.001914415,0.003317246],"study_design_scores_gemma":[0.008151266,0.004244872,0.01180013,0.0001910566,0.0008074308,0.009775702,0.00004067712,0.00006484404,0.9116287,0.003582394,0.04940557,0.0003073777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9580719,0.01153599,0.02873339,0.001051287,0.0002965102,0.0001342975,0.00002525666,0.00000739018,0.0001439217],"genre_scores_gemma":[0.9968614,0.000420663,0.00194068,0.0005724107,0.0001128225,9.493835e-7,0.0000292284,0.00001633254,0.00004549032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0784912,"threshold_uncertainty_score":0.4175402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008263451242907865,"score_gpt":0.2619512948206071,"score_spread":0.2536878435776992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}