{"id":"W1984844116","doi":"10.1006/jmbi.2001.4450","title":"Structure and functionality of a designed p53 dimer11Edited by P. E. Wright","year":2001,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute","keywords":"Transactivation; Tetramer; Mutant; Chemistry; Wild type; Mutation; Oligomer; Denaturation (fissile materials); Cell biology; Biochemistry; Biology; Biophysics; Gene; Transcription factor; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001955822,0.0004542226,0.000343481,0.0001337234,0.0005705928,0.0003620407,0.0006790684,0.0006700637,0.00496236],"category_scores_gemma":[0.0001714594,0.0002525618,0.0003040067,0.0001479918,0.0001925335,0.0002861155,0.0002848537,0.00116899,0.001214208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005302656,"about_ca_system_score_gemma":0.000280199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008623399,"about_ca_topic_score_gemma":0.0007114185,"domain_scores_codex":[0.9998983,0.00001764915,0.000005792629,0.00002402118,0.0000281174,0.0000260072],"domain_scores_gemma":[0.999953,0.000009354027,0.000007082499,0.000004797613,0.000007841593,0.00001791933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008708651,0.0002450615,0.0005075706,0.0002203715,0.00003799551,0.000865655,0.0001417366,0.004261322,0.9789454,0.001711939,0.001629624,0.0105624],"study_design_scores_gemma":[0.0002216698,0.001134234,0.001377576,0.00003791715,0.00005564703,0.0006255701,0.000110537,0.01202257,0.9672132,0.0005048124,0.01663077,0.00006542325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772816,0.002894321,0.0137951,0.0007292414,0.0002303606,0.00007745145,0.0005612207,0.0002565152,0.004174261],"genre_scores_gemma":[0.9779864,0.0011387,0.009327334,0.0001954989,0.00001607215,0.0000566474,0.00134172,0.00005091243,0.009886693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00496236,"threshold_uncertainty_score":0.01660073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008263451242907865,"score_gpt":0.2619512948206071,"score_spread":0.2536878435776992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}