{"id":"W1984878459","doi":"10.1523/jneurosci.5522-06.2007","title":"HIV-1 Vpr Causes Neuronal Apoptosis and<i>In Vivo</i>Neurodegeneration","year":2007,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heritage Medical Research Clinic; St. Paul's Hospital; University of Alberta; Université de Montréal; Montreal Clinical Research Institute; University of Calgary","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Canada Research Chairs","keywords":"Neurodegeneration; Biology; Synaptophysin; Apoptosis; Genetically modified mouse; Transgene; Cell biology; Neurotoxicity; Molecular biology; Neuroscience; Immunology; Internal medicine; Medicine; Toxicity; Biochemistry; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001671209,0.0004691104,0.0002889467,0.000225003,0.0001578651,0.0002658171,0.0002350018,0.0003535975,0.0009135076],"category_scores_gemma":[0.0001229664,0.0001779495,0.0002786442,0.0001088688,0.0002370478,0.0001485824,0.0001487471,0.0009090101,0.0003958042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002466017,"about_ca_system_score_gemma":0.0001465503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007081706,"about_ca_topic_score_gemma":0.0006217619,"domain_scores_codex":[0.9997664,0.00004699334,0.00002714656,0.00004342892,0.00005230166,0.00006373077],"domain_scores_gemma":[0.9998932,0.00001480312,0.00002987896,0.00002122465,0.00001482002,0.00002602103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001905656,0.00008052084,0.0001568842,0.00003848455,0.00001085187,0.0001032261,0.00001248195,0.00002605634,0.9983838,0.00006818963,0.00007891449,0.000850183],"study_design_scores_gemma":[0.00003303313,0.001191969,0.004306753,0.00001836352,0.00002579142,0.0007385478,0.00003893653,0.0004797127,0.9915779,0.00008354286,0.001501381,0.000004240282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925171,0.002565961,0.001691011,0.0001603268,0.00008545225,0.00003126353,0.0003593228,0.0001222867,0.002467361],"genre_scores_gemma":[0.9925056,0.001971403,0.001356948,0.0001167176,0.00002938971,0.000052419,0.0007190196,0.0000313069,0.003217279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009135076,"threshold_uncertainty_score":0.00305599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02394164681529746,"score_gpt":0.2823731199629597,"score_spread":0.2584314731476622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}