{"id":"W1984895700","doi":"10.1016/j.jacc.2009.11.065","title":"Pharmacokinetic and Hemodynamic Responses to Oral Sildenafil During Invasive Testing in Children With Pulmonary Hypertension","year":2010,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Sildenafil; Medicine; Cyclic guanosine monophosphate; Vascular resistance; Pulmonary hypertension; Hemodynamics; cGMP-specific phosphodiesterase type 5; Pharmacokinetics; Vasodilation; Anesthesia; Internal medicine; Heart disease; Nitric oxide; Cardiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003548272,0.0003947282,0.0008416172,0.0002920361,0.0002393915,0.0004981146,0.0002035659,0.0005089621,0.0004708967],"category_scores_gemma":[0.004188301,0.0002155503,0.00035718,0.0003324816,0.000445724,0.0004541306,0.0002410362,0.001378731,0.0001330927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006748118,"about_ca_system_score_gemma":0.0004874578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004680005,"about_ca_topic_score_gemma":0.003714006,"domain_scores_codex":[0.9994763,0.0001358089,0.00003988853,0.00008472886,0.0001570522,0.0001062476],"domain_scores_gemma":[0.9975376,0.001246425,0.0005439878,0.00008606907,0.0001395092,0.0004463962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.003686486,0.0005771352,0.9735054,0.00006300773,0.00008702085,0.002336221,0.0007937769,0.0004428941,0.008387935,0.00008448029,0.0002966313,0.009739064],"study_design_scores_gemma":[0.00005019255,0.002056129,0.9923543,0.000009868825,0.00007169771,0.001916284,0.0004616325,0.0006834776,0.002104426,0.00002118509,0.0002586683,0.00001209473],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992781,0.0001603919,0.00008245745,0.00004662273,0.000008265976,0.000006685557,0.00007606819,0.000006756415,0.0003346206],"genre_scores_gemma":[0.9995075,0.0001301171,0.0001012124,0.00005605659,0.00001650818,0.00001046757,0.00009473222,0.000004326538,0.00007889016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004680005,"threshold_uncertainty_score":0.009305537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01550511369251922,"score_gpt":0.2733714467011986,"score_spread":0.2578663330086794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}