{"id":"W1984912016","doi":"10.1093/nar/gkj455","title":"2'-Deoxy-2'-fluoro- -D-arabinonucleic acid (2'F-ANA) modified oligonucleotides (ON) effect highly efficient, and persistent, gene silencing","year":2006,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; McGill University; National Cancer Institute; Doris Duke Charitable Foundation","keywords":"Biology; Gene silencing; Oligonucleotide; Molecular biology; Gene knockdown; DNA; Gene expression; Nuclease; RNA; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008700867,0.0004406363,0.0001894488,0.00008523914,0.00009283406,0.0002290452,0.0001149235,0.0002476148,0.0008229394],"category_scores_gemma":[0.0001041758,0.00008963078,0.0001537127,0.00006498013,0.0001989104,0.0001294193,0.00007872107,0.0002478701,0.0001847208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001833771,"about_ca_system_score_gemma":0.000157179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005129864,"about_ca_topic_score_gemma":0.0008204873,"domain_scores_codex":[0.9999216,0.00001313732,0.000005505891,0.00002450985,0.00002110261,0.00001423293],"domain_scores_gemma":[0.9999312,0.00002145911,0.00002032588,0.00000682039,0.000008939238,0.00001121353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001134357,0.000003716428,0.00003649598,0.0000099054,0.000001080199,0.00000723113,0.000003620822,0.00002539543,0.9994233,0.00003216676,0.000006035523,0.0004398755],"study_design_scores_gemma":[0.00000162602,0.00009198824,0.0003291895,7.453669e-7,0.000003282556,0.00005689173,0.000003818705,0.0001295242,0.9985135,0.000009443618,0.0008585952,0.000001191201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848674,0.0009053812,0.01084258,0.00004654731,0.00003943921,0.00004380228,0.0001570988,0.0001244732,0.002973276],"genre_scores_gemma":[0.9855613,0.0006991412,0.01041041,0.0000370082,0.000009850935,0.00003978747,0.0001955614,0.00002426145,0.00302257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008229394,"threshold_uncertainty_score":0.00275296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.022563478723901,"score_gpt":0.2883914255622789,"score_spread":0.2658279468383778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}