{"id":"W1984912016","doi":"10.1093/nar/gkj455","title":"2'-Deoxy-2'-fluoro- -D-arabinonucleic acid (2'F-ANA) modified oligonucleotides (ON) effect highly efficient, and persistent, gene silencing","year":2006,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; McGill University; National Cancer Institute; Doris Duke Charitable Foundation","keywords":"Biology; Gene silencing; Oligonucleotide; Molecular biology; Gene knockdown; DNA; Gene expression; Nuclease; RNA; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001130875,0.0003882094,0.0003630754,0.0003194118,0.0005466768,0.0001988284,0.000599609,0.0003406002,0.00005767316],"category_scores_gemma":[0.0001824768,0.000348725,0.0002611565,0.0003476928,0.0004718019,0.00001390462,0.000450227,0.0004941967,0.0002609476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008805942,"about_ca_system_score_gemma":0.00008808929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000244044,"about_ca_topic_score_gemma":0.0000245785,"domain_scores_codex":[0.9964351,0.0004058192,0.0003674407,0.001045202,0.0007200537,0.00102639],"domain_scores_gemma":[0.9984477,0.00009618606,0.00008014802,0.0008391561,0.0002908375,0.0002459393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004210874,0.0001371566,0.001917193,0.00005610286,0.00009224585,0.00003182394,0.00008303991,0.0008258431,0.9857013,0.0002411911,0.005300278,0.005192782],"study_design_scores_gemma":[0.001381374,0.003260632,0.0076044,0.00007905215,0.0000409339,0.00005391859,0.0002180282,0.002271983,0.9812669,0.0000910209,0.003206554,0.0005251757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890525,0.001744833,0.0001395322,0.0002284422,0.0001739207,0.0004634747,0.0000347802,0.00005229572,0.008110265],"genre_scores_gemma":[0.9971611,0.0002659767,0.0002697723,0.0001580806,0.0005263839,0.00005748547,0.00008082928,0.00007779856,0.001402539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008108678,"threshold_uncertainty_score":0.9998965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.022563478723901,"score_gpt":0.2883914255622789,"score_spread":0.2658279468383778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}