{"id":"W1984912202","doi":"10.1021/jm900607f","title":"Development of Novel, Highly Potent Inhibitors of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF): Increasing Cellular Potency through Optimization of a Distal Heteroaromatic Group","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Cancer Research UK; Wellcome Trust","keywords":"Chemistry; Viral Oncogene; Kinase; Potency; In vivo; Melanoma; Oncogene; In vitro; MAPK/ERK pathway; V600E; Mutant; Cancer research; Pharmacology; Biochemistry; Biology; Cell; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001308332,0.0003495021,0.0002533872,0.0001640834,0.0001136744,0.0001964801,0.0003268353,0.000241579,0.0008617969],"category_scores_gemma":[0.00006874458,0.0001256503,0.0001810635,0.0001358056,0.0001346451,0.0001943389,0.0001393142,0.0004588208,0.0003536784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001915615,"about_ca_system_score_gemma":0.000223183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003302053,"about_ca_topic_score_gemma":0.001430933,"domain_scores_codex":[0.9999434,0.000007909081,0.000004671973,0.00001109376,0.00001859387,0.00001435489],"domain_scores_gemma":[0.9999577,0.000004977897,0.00001417041,0.000003671542,0.000007076084,0.00001245442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001128777,0.0001549178,0.0001371,0.0001046007,0.00001087525,0.0001094557,0.00003110126,0.0008877847,0.9887205,0.0002501533,0.0001012192,0.00937947],"study_design_scores_gemma":[0.0001866308,0.004012041,0.00210702,0.00001163076,0.00005303048,0.0006981299,0.00002196356,0.001527172,0.9798775,0.00009076447,0.01139368,0.00002032433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975517,0.007350327,0.01220245,0.0001523943,0.00004281201,0.0002574742,0.0003503835,0.0001414496,0.003985734],"genre_scores_gemma":[0.9762821,0.00690007,0.01249227,0.000104134,0.00003272537,0.000109649,0.0005857281,0.00001964533,0.003473733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008617969,"threshold_uncertainty_score":0.002883017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008721649390379867,"score_gpt":0.2220258082337312,"score_spread":0.2133041588433514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}