{"id":"W1984912202","doi":"10.1021/jm900607f","title":"Development of Novel, Highly Potent Inhibitors of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF): Increasing Cellular Potency through Optimization of a Distal Heteroaromatic Group","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Cancer Research UK; Wellcome Trust","keywords":"Chemistry; Viral Oncogene; Kinase; Potency; In vivo; Melanoma; Oncogene; In vitro; MAPK/ERK pathway; V600E; Mutant; Cancer research; Pharmacology; Biochemistry; Biology; Cell; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005637237,0.0002174655,0.0005036934,0.00005421588,0.00004295297,0.000004747193,0.0003001754,0.00024187,0.00002542311],"category_scores_gemma":[0.0002339819,0.0001818487,0.0001900304,0.00009408153,0.0002104853,0.00001499312,0.000120161,0.000272421,1.401632e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002868119,"about_ca_system_score_gemma":0.0002852754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003100242,"about_ca_topic_score_gemma":0.000004759256,"domain_scores_codex":[0.9978486,0.00003770876,0.001217756,0.0001923719,0.0004966787,0.000206932],"domain_scores_gemma":[0.9979882,0.0000269776,0.001283541,0.0002625468,0.0003031107,0.0001355704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003573487,0.000546888,0.0004695206,0.0004826553,0.0001303799,0.00004097564,0.0002254537,0.0001891532,0.9966406,0.000008678518,0.00003187799,0.0008765223],"study_design_scores_gemma":[0.001917774,0.00057109,0.0004283661,0.0003209068,0.00009601631,0.0006090991,0.0002479091,0.0001318105,0.9952436,0.00001959156,0.0002565944,0.0001572325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828181,0.000509555,0.01596478,0.0000421062,0.0002606038,0.00008845171,0.00001947034,0.000003098544,0.0002937886],"genre_scores_gemma":[0.9380819,0.00004336005,0.0613305,0.00001527046,0.0003898822,0.000002038035,0.0000971672,0.00002003033,0.00001989947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04536572,"threshold_uncertainty_score":0.7415575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008721649390379867,"score_gpt":0.2220258082337312,"score_spread":0.2133041588433514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}