{"id":"W1985041383","doi":"10.1110/ps.4390102","title":"Covalent cross‐linking of proteins without chemical reagents","year":2002,"lang":"en","type":"article","venue":"Protein Science","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"Health Canada","keywords":"Covalent bond; Dimer; Chemistry; Molecule; RNase P; Peptide bond; Monomer; Reagent; Amide; Lysozyme; Macromolecule; Stereochemistry; Organic chemistry; Enzyme; Biochemistry; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006400355,0.000110265,0.0002121161,0.0001238966,0.000158032,0.00003712945,0.0003582391,0.00004764739,0.000449983],"category_scores_gemma":[0.0003399304,0.0000810787,0.00007084903,0.0005787717,0.001334224,0.0001413396,0.0002020832,0.0002245783,0.0001223234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005744923,"about_ca_system_score_gemma":0.0001158935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006477958,"about_ca_topic_score_gemma":8.378884e-7,"domain_scores_codex":[0.997672,0.00001977062,0.0002735616,0.0003581519,0.001248824,0.0004277485],"domain_scores_gemma":[0.9990715,0.0000188693,0.00008301405,0.0003094883,0.0002827182,0.0002343675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001051211,0.0001830888,0.04529329,0.0002031854,0.000008123391,0.00002008227,0.0001967121,0.000001146299,0.9432155,0.0005683886,0.00002349855,0.01018189],"study_design_scores_gemma":[0.0005581841,0.0002363271,0.0138529,0.0003331694,0.000006425677,0.00005594898,0.00001009237,0.002310683,0.9801129,0.0002489732,0.002160235,0.0001142108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869757,0.0002527397,0.0001138357,0.0006595592,0.00003717084,0.0008529177,0.000005007516,0.00002787655,0.0110752],"genre_scores_gemma":[0.9869448,0.00002216152,0.00743705,0.0000853957,0.00008648901,0.00005553626,0.000001448758,0.000008629488,0.005358511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03689737,"threshold_uncertainty_score":0.4926998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0695322644299905,"score_gpt":0.3663172808726743,"score_spread":0.2967850164426838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}