{"id":"W1985041383","doi":"10.1110/ps.4390102","title":"Covalent cross‐linking of proteins without chemical reagents","year":2002,"lang":"en","type":"article","venue":"Protein Science","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"Health Canada","keywords":"Covalent bond; Dimer; Chemistry; Molecule; RNase P; Peptide bond; Monomer; Reagent; Amide; Lysozyme; Macromolecule; Stereochemistry; Organic chemistry; Enzyme; Biochemistry; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004827487,0.0006517885,0.0002867447,0.0002858303,0.0002430835,0.0003494719,0.0007428681,0.000505854,0.001661993],"category_scores_gemma":[0.0004170443,0.0003503331,0.0004132905,0.0002654762,0.0004074146,0.0004348792,0.0005181587,0.0008453349,0.0007501956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002946721,"about_ca_system_score_gemma":0.000268218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002110623,"about_ca_topic_score_gemma":0.0003648764,"domain_scores_codex":[0.9996471,0.00005160278,0.00002554554,0.000112115,0.0001121935,0.00005152842],"domain_scores_gemma":[0.9997311,0.00006972229,0.00007148878,0.0000542191,0.00003647771,0.00003689052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001596571,0.00001983073,0.00006141969,0.0000734831,0.00001284548,0.00003565948,0.0000150391,0.00005114053,0.9963214,0.0003410995,0.00007358136,0.002978563],"study_design_scores_gemma":[0.000003925151,0.00007809241,0.0001992614,0.000003793897,0.00001184191,0.00009925963,0.000003425403,0.0001768371,0.9950428,0.00006144649,0.004315898,0.000003396701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6989254,0.01198571,0.2779947,0.0004625114,0.0003655557,0.0004179454,0.0004982225,0.001141452,0.008208517],"genre_scores_gemma":[0.84688,0.009454928,0.1260735,0.0004459712,0.00008831337,0.0004190462,0.001455309,0.0001759869,0.01500699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001661993,"threshold_uncertainty_score":0.005559921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0695322644299905,"score_gpt":0.3663172808726743,"score_spread":0.2967850164426838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}