{"id":"W1985042270","doi":"10.1016/j.ymgme.2013.10.016","title":"Holocarboxylase synthetase acts as a biotin-independent transcriptional repressor interacting with HDAC1, HDAC2 and HDAC7","year":2013,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Consejo Nacional de Ciencia y Tecnología; University of Calgary","keywords":"Histone deacetylase 2; Repressor; Biology; Histone deacetylase 5; Histone methyltransferase; Chromatin immunoprecipitation; Transcriptional regulation; Chromatin; Molecular biology; Histone H2A; Psychological repression; YY1; Regulation of gene expression; GATAD2B; Histone; Histone deacetylase; Transcription factor; Gene expression; Promoter; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000237231,0.0006025461,0.0005915051,0.0002834482,0.0005095779,0.0007234714,0.0005550901,0.0003256397,0.00340418],"category_scores_gemma":[0.0001825996,0.0003057859,0.0006310642,0.0002516034,0.0004240102,0.0003993124,0.000457445,0.0006170536,0.0017324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001211051,"about_ca_system_score_gemma":0.0005001568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00218281,"about_ca_topic_score_gemma":0.005171932,"domain_scores_codex":[0.9997476,0.00003415196,0.00001246276,0.00007726334,0.0000683158,0.00006021924],"domain_scores_gemma":[0.999837,0.00003084889,0.00002798673,0.00002131603,0.00003000893,0.0000526661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002199577,0.00001661325,0.0005453958,0.00005720342,0.00002036991,0.00006673174,0.00001430596,0.00006397755,0.9964095,0.0002867078,0.0001525278,0.002146788],"study_design_scores_gemma":[0.000011052,0.0000325285,0.002293657,0.000003204052,0.00001220482,0.0001137755,0.00002523,0.0005987008,0.9935475,0.00005741996,0.003299827,0.000004983267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9425595,0.008447701,0.03264734,0.0006603343,0.0003037128,0.0000977122,0.001400921,0.0009003356,0.01298256],"genre_scores_gemma":[0.9707453,0.001646947,0.009294278,0.0001338102,0.00004259736,0.00004108206,0.001962417,0.0001379796,0.01599559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00340418,"threshold_uncertainty_score":0.01138806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003886398712407789,"score_gpt":0.2074639939678733,"score_spread":0.2035775952554655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}