{"id":"W1985060701","doi":"10.1159/000285514","title":"Early-Stage Inflammation and Experimental Therapy in Transgenic Models of the Alzheimer-Like Amyloid Pathology","year":2010,"lang":"en","type":"article","venue":"Neurodegenerative Diseases","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; McGill University; Regione Autonoma della Sardegna; Alzheimer's Association","keywords":"Genetically modified mouse; Proinflammatory cytokine; Microglia; Hippocampus; Neuropathology; Transgene; Neurodegeneration; Neuroinflammation; Alzheimer's disease; Amyloid (mycology); Pathology; Neuroscience; Amyloid precursor protein; Inflammation; Medicine; Biology; Immunology; Disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004438213,0.0001750502,0.0002249521,0.0000813174,0.00008640502,0.00001533983,0.00009014687,0.00005682007,0.00008367447],"category_scores_gemma":[0.00001822954,0.0001166741,0.0001126697,0.0001292797,0.0002823302,0.0001351124,0.00003815901,0.000179095,0.000003004966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001030039,"about_ca_system_score_gemma":0.0001342151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006038105,"about_ca_topic_score_gemma":0.00004462895,"domain_scores_codex":[0.9988418,0.0001646701,0.0002052006,0.0003043048,0.0002689408,0.0002151509],"domain_scores_gemma":[0.9993298,0.00004593414,0.00006142518,0.0003050286,0.00007230113,0.0001854868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002655114,0.002377032,0.2703891,0.00003670409,0.00176155,0.0001883702,0.002371768,0.0002317551,0.7130997,0.001728936,0.00007084382,0.005089059],"study_design_scores_gemma":[0.003850651,0.0005952185,0.4533382,0.00001774431,0.000181563,0.000009684052,0.0001142283,0.0008619934,0.5406859,0.0001811113,0.00002723358,0.0001365083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928674,0.005769016,0.000003915046,0.0001752628,0.00008553973,0.000788025,0.0001280584,0.00001851432,0.0001643029],"genre_scores_gemma":[0.9993294,0.0002554555,0.00004018369,0.000103809,0.0000538484,0.0001394357,0.00003372007,0.00002246017,0.00002172418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.182949,"threshold_uncertainty_score":0.4757831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0357700254720036,"score_gpt":0.3101091872241448,"score_spread":0.2743391617521412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}