{"id":"W1985060701","doi":"10.1159/000285514","title":"Early-Stage Inflammation and Experimental Therapy in Transgenic Models of the Alzheimer-Like Amyloid Pathology","year":2010,"lang":"en","type":"article","venue":"Neurodegenerative Diseases","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; McGill University; Regione Autonoma della Sardegna; Alzheimer's Association","keywords":"Genetically modified mouse; Proinflammatory cytokine; Microglia; Hippocampus; Neuropathology; Transgene; Neurodegeneration; Neuroinflammation; Alzheimer's disease; Amyloid (mycology); Pathology; Neuroscience; Amyloid precursor protein; Inflammation; Medicine; Biology; Immunology; Disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006972243,0.001014973,0.000717933,0.0007097712,0.0003661444,0.0004252505,0.0005473032,0.0006758522,0.001845979],"category_scores_gemma":[0.0002243941,0.0001756843,0.0004429652,0.0003623995,0.0007500083,0.0005034968,0.0003459954,0.001244562,0.000466353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004222729,"about_ca_system_score_gemma":0.0004780365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003083639,"about_ca_topic_score_gemma":0.0007102533,"domain_scores_codex":[0.999689,0.00008318101,0.00003446592,0.00006085316,0.00006992096,0.00006264286],"domain_scores_gemma":[0.9998075,0.00002585261,0.00006494346,0.0000294543,0.00002210823,0.00005011813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001941119,0.002176224,0.0002360402,0.0005220862,0.00002444515,0.0003692463,0.0000990259,0.0001549054,0.9827347,0.001200578,0.0003957958,0.01014574],"study_design_scores_gemma":[0.0009332665,0.01713356,0.004467375,0.0002328442,0.0001939716,0.00157951,0.00009708818,0.0007958995,0.9448311,0.001269272,0.02842929,0.00003685941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9447402,0.02202512,0.02148119,0.001096374,0.0007179061,0.001269161,0.001108383,0.0006552781,0.00690638],"genre_scores_gemma":[0.9348087,0.02217119,0.02545271,0.0004581742,0.0002597317,0.002665535,0.001401322,0.0001018702,0.01268063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001845979,"threshold_uncertainty_score":0.006175458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0357700254720036,"score_gpt":0.3101091872241448,"score_spread":0.2743391617521412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}