{"id":"W1985077504","doi":"10.1021/bi100020e","title":"Protein Kinase Cε Regulation of Translocator Protein (18 kDa)<i>Tspo</i>Gene Expression Is Mediated through a MAPK Pathway Targeting STAT3 and c-Jun Transcription Factors","year":2010,"lang":"en","type":"article","venue":"Biochemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Institute of Environmental Health Sciences","keywords":"Gene knockdown; AP-1 transcription factor; Protein kinase C; Translocator protein; STAT3; MAPK/ERK pathway; Molecular biology; Biology; Signal transduction; Transcription factor; STAT protein; Cell biology; Chemistry; Apoptosis; Gene; Biochemistry; Immunology; Neuroinflammation; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000186323,0.0003132755,0.0002372453,0.00003183871,0.000116466,0.00002207178,0.000156594,0.0006902321,0.00005699107],"category_scores_gemma":[0.00009007152,0.0002751262,0.0001277193,0.0001241705,0.0001542339,0.00001642847,0.00003889326,0.0003021928,0.000001996637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001235053,"about_ca_system_score_gemma":0.0001133754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002748483,"about_ca_topic_score_gemma":0.000001749877,"domain_scores_codex":[0.9984637,0.00005825247,0.0003818857,0.0005499481,0.0002417807,0.0003044375],"domain_scores_gemma":[0.9991562,0.000009966411,0.0002065082,0.0003699668,0.0001069861,0.0001503607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002326657,0.0001225828,0.0002074122,0.000250394,0.00003994652,0.000002713896,0.0003145024,0.000001107368,0.9983989,0.000006880001,0.0002066934,0.0002162088],"study_design_scores_gemma":[0.0009682123,0.0001869366,0.0001866728,0.0001117127,0.0000240822,0.000006459923,0.0001182259,0.0000384234,0.9969811,0.00004630696,0.001016675,0.0003151808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996925,0.00142151,0.0005529225,0.00007722869,0.00008153396,0.0006508818,0.0001384867,0.00003831897,0.0001141304],"genre_scores_gemma":[0.99554,0.00005449844,0.00297299,0.000023383,0.000142288,0.0000734507,0.0008177765,0.00004555707,0.000330066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002420068,"threshold_uncertainty_score":0.9999701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006616719573669392,"score_gpt":0.2154652703475362,"score_spread":0.2088485507738668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}