{"id":"W1985077504","doi":"10.1021/bi100020e","title":"Protein Kinase Cε Regulation of Translocator Protein (18 kDa)<i>Tspo</i>Gene Expression Is Mediated through a MAPK Pathway Targeting STAT3 and c-Jun Transcription Factors","year":2010,"lang":"en","type":"article","venue":"Biochemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Institute of Environmental Health Sciences","keywords":"Gene knockdown; AP-1 transcription factor; Protein kinase C; Translocator protein; STAT3; MAPK/ERK pathway; Molecular biology; Biology; Signal transduction; Transcription factor; STAT protein; Cell biology; Chemistry; Apoptosis; Gene; Biochemistry; Immunology; Neuroinflammation; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000749137,0.0003036657,0.0001175293,0.0001712252,0.0001711963,0.000188556,0.0001161788,0.0001112121,0.001707559],"category_scores_gemma":[0.00007513427,0.00008536286,0.000318437,0.0001138161,0.0001959602,0.0001334805,0.0001493464,0.0003865484,0.0003484931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003661352,"about_ca_system_score_gemma":0.0002291945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001001967,"about_ca_topic_score_gemma":0.001028358,"domain_scores_codex":[0.9998831,0.00001226668,0.000008558297,0.00002214379,0.00002303899,0.00005087749],"domain_scores_gemma":[0.9999369,0.00000796945,0.00002325496,0.000004754285,0.000009974227,0.00001706691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001470432,0.00001914265,0.0002340702,0.00004591093,0.000003230861,0.00003205714,0.00001335626,0.00003287565,0.9982015,0.0001175256,0.00006719468,0.001086083],"study_design_scores_gemma":[0.00003076676,0.0001507476,0.01581979,0.00001129467,0.00001178731,0.000280194,0.00004781591,0.001089963,0.9789451,0.0001127117,0.003495176,0.000004688765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891312,0.002534741,0.004624618,0.0002189679,0.00006977894,0.00002359676,0.0004504634,0.0001174324,0.002829126],"genre_scores_gemma":[0.9938096,0.001235128,0.001706882,0.00006486941,0.00001545988,0.00003226734,0.0004712656,0.00001384623,0.002650741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001707559,"threshold_uncertainty_score":0.00571233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006616719573669392,"score_gpt":0.2154652703475362,"score_spread":0.2088485507738668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}