{"id":"W1985105947","doi":"10.2337/diabetes.53.6.1475","title":"The Role of Calcium/Calmodulin-Dependent Protein Kinase Cascade in Glucose Upregulation of Insulin Gene Expression","year":2004,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Downregulation and upregulation; Insulin; Calmodulin; Internal medicine; Endocrinology; Insulin receptor; Biology; Transfection; Chemistry; Cell culture; Calcium; Gene; Insulin resistance; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002789259,0.0001200905,0.0002898579,0.000101651,0.00004092909,0.000006222713,0.0000797887,0.00009853444,0.00002666836],"category_scores_gemma":[0.0003777726,0.0000822135,0.00007459474,0.0001972712,0.00009357494,0.0000618896,0.00003780569,0.0001136108,0.000008176001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006308794,"about_ca_system_score_gemma":0.0000811034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00010946,"about_ca_topic_score_gemma":0.000003506588,"domain_scores_codex":[0.9988517,0.00005768221,0.0004093102,0.0001741501,0.000294446,0.0002127038],"domain_scores_gemma":[0.9992592,0.0001019116,0.0001586099,0.0003071513,0.0000942108,0.00007887054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000111283,0.000249519,0.03154878,0.00006905295,0.00001808957,0.000001640546,0.000212272,0.0002478304,0.960613,0.0002577098,0.000004009616,0.006666881],"study_design_scores_gemma":[0.001937939,0.0001834447,0.04908547,0.0003374581,0.00002385394,5.040939e-7,0.0001721683,0.0004666015,0.9453042,0.002322708,0.00009316508,0.0000724978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948953,0.003866543,0.00003705296,0.0001449066,0.00005205521,0.0005172036,0.00001082189,0.00002211931,0.0004540134],"genre_scores_gemma":[0.9988232,0.0000328714,0.0008791002,0.00003505159,0.000050819,0.0000702404,0.00002183393,0.00001437265,0.00007251853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01753669,"threshold_uncertainty_score":0.3352569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01028026792724785,"score_gpt":0.2388264124182396,"score_spread":0.2285461444909917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}