{"id":"W1985139869","doi":"10.1016/j.mad.2008.05.005","title":"Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle","year":2008,"lang":"en","type":"article","venue":"Mechanisms of Ageing and Development","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":173,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Aging","funders":"National Institute on Aging; Università Cattolica del Sacro Cuore","keywords":"Mitochondrial permeability transition pore; Apoptosis; Mitochondrion; Apoptosis-inducing factor; Skeletal muscle; Biology; Cytochrome c; Cell biology; Mitochondrial apoptosis-induced channel; DNA fragmentation; Gastrocnemius muscle; Internal medicine; Endocrinology; Caspase 3; Sarcopenia; Mitochondrial membrane transport protein; Fragmentation (computing); Caspase; Programmed cell death; Biochemistry; Medicine; Inner mitochondrial membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001487848,0.0001235443,0.0001984721,0.0001069134,0.00006480133,0.000003844415,0.00006711463,0.0001475277,0.00002936506],"category_scores_gemma":[0.00005951857,0.0001240564,0.00003696645,0.00007906974,0.00004011903,0.000004783936,0.00005771445,0.00008400331,0.000001803006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000163368,"about_ca_system_score_gemma":0.00009803037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004044955,"about_ca_topic_score_gemma":0.00002813314,"domain_scores_codex":[0.9990045,0.00005957407,0.0003773306,0.0002545038,0.000142595,0.0001614913],"domain_scores_gemma":[0.9996198,0.00001563337,0.0001409858,0.0001209653,0.0000527563,0.00004990321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001155029,0.00005265146,0.0001259803,0.00002359544,0.00001754949,0.00003135108,0.0004511093,0.0003680339,0.9977331,0.00009553556,0.00003503322,0.0009505333],"study_design_scores_gemma":[0.001110457,0.0001968119,0.001622921,0.00005122206,0.000005379964,0.00003008853,0.000192871,0.00001791093,0.996165,0.000166849,0.0003145068,0.0001259498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9475312,0.00004320708,0.05178645,0.00001380479,0.0003371515,0.0001567501,0.000001433754,0.00000732685,0.00012274],"genre_scores_gemma":[0.9723027,0.00002408237,0.02729663,0.00003537306,0.00003524851,0.00001189956,0.00005442066,0.00001130462,0.0002283623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02477155,"threshold_uncertainty_score":0.5058874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01471289481937643,"score_gpt":0.2179869883961957,"score_spread":0.2032740935768193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}