{"id":"W1985144105","doi":"10.1158/1538-7445.fbcr13-a09","title":"Abstract A09: Downregulation of PI3K signaling by high ERK activity prevents transformation by oncogenic RAS","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"MAPK/ERK pathway; PI3K/AKT/mTOR pathway; Protein kinase B; Cell biology; Biology; Signal transduction; PTEN; Cancer research; Senescence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001089312,0.0003352427,0.0002729945,0.0002514779,0.0001691748,0.0002794589,0.0002672967,0.0002470745,0.00268852],"category_scores_gemma":[0.0001254228,0.0001184787,0.000294051,0.0001587797,0.0002205553,0.0001604047,0.0002045182,0.0008580888,0.0007418236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002062311,"about_ca_system_score_gemma":0.0002410068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004642876,"about_ca_topic_score_gemma":0.0005237258,"domain_scores_codex":[0.9998189,0.00002796944,0.00003005836,0.00002853121,0.00004890688,0.00004580722],"domain_scores_gemma":[0.999833,0.00003400579,0.00003523557,0.00002656413,0.00001355865,0.00005753517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003308783,0.0002123113,0.0001138171,0.00002172118,0.000004150907,0.00003339418,0.000006465359,0.00004773796,0.9978526,0.0001025948,0.00005847171,0.001215878],"study_design_scores_gemma":[0.00003140983,0.0007987663,0.001512346,0.000003132501,0.000009017425,0.0001504697,0.00001122367,0.0007376251,0.9953517,0.00003672297,0.001355033,0.000002595894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995737,0.0005472776,0.001424938,0.00007726532,0.00004017098,0.0000328383,0.0005087809,0.0001113123,0.001520432],"genre_scores_gemma":[0.99452,0.0003139812,0.001440876,0.00003482613,0.00001072624,0.00004522237,0.001061791,0.00003502321,0.002537565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00268852,"threshold_uncertainty_score":0.008994043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0255236605092468,"score_gpt":0.3437683311013616,"score_spread":0.3182446705921148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}