{"id":"W1985241942","doi":"10.1042/bj20150125","title":"Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity","year":2015,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Metformin; AMPK; Lipogenesis; Insulin resistance; Pharmacology; AMP-activated protein kinase; Endocrinology; Internal medicine; Insulin; Acetyl-CoA carboxylase; Type 2 diabetes; Chemistry; Protein kinase A; Medicine; Pyruvate carboxylase; Lipid metabolism; Biochemistry; Diabetes mellitus; Phosphorylation; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001588755,0.000393974,0.0003648934,0.0003118472,0.0001536665,0.0002594193,0.0001546461,0.0002654653,0.002329483],"category_scores_gemma":[0.0001109986,0.0001729336,0.0003636818,0.0002419646,0.0001772526,0.0002079279,0.0002684759,0.0004205454,0.0003241904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001692512,"about_ca_system_score_gemma":0.0002338364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001984875,"about_ca_topic_score_gemma":0.0009385322,"domain_scores_codex":[0.9998364,0.0000481225,0.00001504554,0.00002315898,0.00004829316,0.0000289708],"domain_scores_gemma":[0.9999391,0.000009181184,0.00002030924,0.000006723687,0.000005462671,0.00001926031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001495251,0.0002450397,0.0008153595,0.000170313,0.00004412812,0.00008937414,0.00001458997,0.0001979844,0.9850227,0.000203071,0.0001728023,0.01152934],"study_design_scores_gemma":[0.0003967732,0.007325644,0.01991243,0.00003455617,0.0001551209,0.0006252444,0.00006286275,0.00105035,0.9612762,0.000254359,0.008890266,0.0000161367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845657,0.00826885,0.002419618,0.0004201063,0.00009311373,0.00008147759,0.0002888698,0.00007778207,0.003784443],"genre_scores_gemma":[0.9916016,0.003556181,0.002573357,0.0001521116,0.00004226514,0.00005789633,0.0001932443,0.000008484039,0.001814799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002329483,"threshold_uncertainty_score":0.00779283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01477156185061433,"score_gpt":0.2355891613768144,"score_spread":0.2208175995262001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}