{"id":"W1985262162","doi":"10.1007/s00439-014-1515-4","title":"Candidate locus analysis of the TERT–CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk","year":2014,"lang":"en","type":"article","venue":"Human Genetics","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institute on Aging; Wellcome Trust; Francis Crick Institute; National Cancer Institute; Cancer Research UK","keywords":"Endometrial cancer; Biology; Single-nucleotide polymorphism; Locus (genetics); SNP; Genetics; Cancer; Haplotype; Genotype; Oncology; Gene; Bioinformatics; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007377815,0.0004504981,0.0004829054,0.00101456,0.000266548,0.0004572695,0.0005788305,0.0005435044,0.00232691],"category_scores_gemma":[0.002488383,0.000210319,0.001144606,0.001045642,0.000300643,0.00009969265,0.0004819281,0.0004647792,0.0002591714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003076542,"about_ca_system_score_gemma":0.0002586887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002256949,"about_ca_topic_score_gemma":0.00225821,"domain_scores_codex":[0.9993891,0.0001675993,0.00004583528,0.0002432925,0.00009979184,0.00005438445],"domain_scores_gemma":[0.9990514,0.0003644476,0.0003659057,0.0000667545,0.00004320052,0.0001083433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002778968,0.0000941918,0.8602976,0.000155308,0.001130872,0.004418539,0.0002864452,0.001507172,0.1025907,0.0003515182,0.0005619892,0.0258267],"study_design_scores_gemma":[0.0001882495,0.0004850748,0.9815565,0.00002794044,0.0003989169,0.003389465,0.00005397497,0.004956979,0.007760168,0.0002653292,0.0008984494,0.00001895086],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957065,0.0007802456,0.002516265,0.0001122349,0.00001222977,0.00003475699,0.000498812,0.00004510509,0.0002938738],"genre_scores_gemma":[0.9963303,0.0001195563,0.002687776,0.00005754231,0.00001393926,0.00002304808,0.0005181623,0.000008230234,0.0002415839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00232691,"threshold_uncertainty_score":0.007784247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01005412270897536,"score_gpt":0.2393153234855926,"score_spread":0.2292612007766173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}