{"id":"W1985264699","doi":"10.1155/2012/398207","title":"Disruption of the<i>ECM33</i>Gene in<i>Candida albicans</i>Prevents Biofilm Formation, Engineered Human Oral Mucosa Tissue Damage and Gingival Cell Necrosis/Apoptosis","year":2012,"lang":"en","type":"article","venue":"Mediators of Inflammation","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Candida albicans; Biofilm; Basement membrane; Mutant; Apoptosis; Gene; Microbiology; Laminin; Biology; Oral mucosa; Gene expression; Necrosis; Molecular biology; Cell biology; Extracellular matrix; Bacteria; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004007879,0.0001456391,0.0003033125,0.0002947499,0.00005871066,0.000009796746,0.00007182252,0.0001001231,0.00007840929],"category_scores_gemma":[0.00009050964,0.0001183351,0.00009059573,0.0004096806,0.00007939783,0.0004229984,0.00004002752,0.0001152019,0.000004497563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006481515,"about_ca_system_score_gemma":0.00002725974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001022971,"about_ca_topic_score_gemma":0.0000359981,"domain_scores_codex":[0.9986368,0.00007756693,0.0006137334,0.0001176666,0.0003516646,0.0002025095],"domain_scores_gemma":[0.9991679,0.00003323724,0.0003561473,0.0002275081,0.00009700072,0.0001181811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002291373,0.0001148374,0.06183806,0.0002670735,0.00001998446,3.3562e-7,0.001580042,0.0000450116,0.9349783,0.00008783206,0.0001260406,0.0009195713],"study_design_scores_gemma":[0.001252186,0.00004853825,0.1071163,0.0002275279,0.00009847674,0.000002515836,0.0002216657,0.0004938532,0.8902127,0.00004382858,0.0001793998,0.0001030127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987112,0.00005805227,0.0003007574,0.0002998854,0.00006393794,0.0003096472,0.0000285061,0.00002068603,0.0002073211],"genre_scores_gemma":[0.9991298,0.00003284096,0.0003814958,0.00004418175,0.0001103424,0.00002095161,0.0001806502,0.00001347048,0.00008623751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0452782,"threshold_uncertainty_score":0.4825566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007799866660782321,"score_gpt":0.2480371539358771,"score_spread":0.2402372872750948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}