{"id":"W1985264699","doi":"10.1155/2012/398207","title":"Disruption of the<i>ECM33</i>Gene in<i>Candida albicans</i>Prevents Biofilm Formation, Engineered Human Oral Mucosa Tissue Damage and Gingival Cell Necrosis/Apoptosis","year":2012,"lang":"en","type":"article","venue":"Mediators of Inflammation","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Candida albicans; Biofilm; Basement membrane; Mutant; Apoptosis; Gene; Microbiology; Laminin; Biology; Oral mucosa; Gene expression; Necrosis; Molecular biology; Cell biology; Extracellular matrix; Bacteria; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007707015,0.000311214,0.0001601181,0.0001475588,0.0001203919,0.0002621071,0.0001673378,0.0002150236,0.0009311621],"category_scores_gemma":[0.00008173571,0.00008940005,0.0002007115,0.0001125521,0.0001963492,0.0001026934,0.0001210763,0.0004719916,0.0002135591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000193068,"about_ca_system_score_gemma":0.0002286315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007604912,"about_ca_topic_score_gemma":0.0009089803,"domain_scores_codex":[0.999881,0.00001507134,0.00001617163,0.00002291636,0.00003701486,0.00002769297],"domain_scores_gemma":[0.999907,0.00001222142,0.00003947046,0.00001232836,0.00001017456,0.00001878196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003214207,0.00001071429,0.00005954659,0.000009824752,0.000001478584,0.00002545495,0.000003071825,0.00001410079,0.9994944,0.00003059547,0.000009070349,0.0003095198],"study_design_scores_gemma":[0.000004146468,0.0000939617,0.001607231,0.00000268261,0.000006947433,0.0001779516,0.00001437831,0.0001771564,0.9970973,0.0000120119,0.0008044812,0.000001813095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996024,0.0004353545,0.002325322,0.00007617757,0.00002101499,0.0000238808,0.0002907788,0.00003610481,0.0007673732],"genre_scores_gemma":[0.9932417,0.0004041543,0.004101438,0.00004683631,0.000005679137,0.00002599564,0.0004431308,0.00002337577,0.001707579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009311621,"threshold_uncertainty_score":0.003115058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007799866660782321,"score_gpt":0.2480371539358771,"score_spread":0.2402372872750948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}