{"id":"W1985265438","doi":"10.1093/nar/gku1390","title":"DNA-mediated cooperativity facilitates the co-selection of cryptic enhancer sequences by SOX2 and PAX6 transcription factors","year":2015,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Toronto","funders":"","keywords":"Biology; Cooperativity; Enhancer; DNA; Genetics; Transcription factor; Transcription (linguistics); PAX6; Computational biology; Cooperative binding; Gene; Binding site","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001915047,0.0001593974,0.0001797351,0.0001192342,0.0001460817,0.0002577927,0.0002462167,0.0001439363,0.001447991],"category_scores_gemma":[0.0002623198,0.0001717601,0.0001375142,0.00007186109,0.0002888754,0.0001982984,0.0003890293,0.0002665478,0.0003067846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001527641,"about_ca_system_score_gemma":0.0001327245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000250334,"about_ca_topic_score_gemma":0.0008111441,"domain_scores_codex":[0.9998275,0.00003473002,0.000007306829,0.00004519659,0.00005239057,0.00003277628],"domain_scores_gemma":[0.9998331,0.0000491108,0.00003705939,0.00002352634,0.00001227186,0.00004489659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005547795,0.000009632333,0.0007085689,0.00001209011,0.000003682503,0.00004804743,0.00001864522,0.0001683142,0.9979321,0.0002585073,0.00001266637,0.0007724017],"study_design_scores_gemma":[0.00001733689,0.00008465777,0.005779061,0.000003561031,0.0000083715,0.0002431444,0.00005185306,0.006636948,0.9856758,0.0003144077,0.001179009,0.000005790336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960384,0.0001580218,0.002798341,0.00001892315,0.000004694426,0.000004667431,0.00001648827,0.00003549175,0.0009249256],"genre_scores_gemma":[0.9989074,0.0000290363,0.0006441448,0.000006506261,0.00000121699,0.000003402871,0.00001886506,0.00000531586,0.0003840613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001447991,"threshold_uncertainty_score":0.004844069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03913740705901358,"score_gpt":0.3176595141329068,"score_spread":0.2785221070738932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}