{"id":"W1985269876","doi":"10.1158/1538-7445.am2013-2474","title":"Abstract 2474: Synthesis and antiproliferative activity of novel 17β-acetyl-testosterone-7α-platinum(II) hybrids designed for the treatment of human prostate cancer.","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"","keywords":"Prostate cancer; LNCaP; DU145; Medicine; Cancer; Cancer research; Testosterone (patch); Internal medicine; Prostate; Androgen receptor; Bicalutamide; Oncology; Androgen; Endocrinology; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005906003,0.0001915803,0.000566729,0.0001070971,0.0003834571,0.00003666514,0.0001379309,0.00005732846,0.0004589567],"category_scores_gemma":[0.0001830274,0.0001085306,0.0001030788,0.0001568293,0.0005413925,0.0001253525,0.00005677866,0.0001339365,0.00000171037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000149387,"about_ca_system_score_gemma":0.0002692942,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007505355,"about_ca_topic_score_gemma":0.000379552,"domain_scores_codex":[0.9984323,0.0001081962,0.0003145834,0.0003228636,0.0004318413,0.0003902442],"domain_scores_gemma":[0.9977625,0.00105287,0.0001495447,0.0003777902,0.0005484185,0.0001089035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000977219,0.0004227511,0.003485132,0.0004836621,0.000270051,5.515458e-7,0.001646929,0.000007426077,0.9298998,0.00003295939,0.0003223474,0.06245124],"study_design_scores_gemma":[0.001215629,0.002432693,0.05270869,0.0003510572,0.00009374085,0.000002178105,0.000347086,0.000270763,0.9418264,0.00002725965,0.000617541,0.0001069299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916471,0.003787007,0.00002331934,0.001173275,0.00003445841,0.00286052,0.0001851511,0.00001105318,0.0002780708],"genre_scores_gemma":[0.9937732,0.001804596,0.0002391184,0.00001354874,0.0001060037,0.002783186,0.000003144091,0.00003330269,0.001243884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06234431,"threshold_uncertainty_score":0.9991037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2380581435061947,"score_gpt":0.4214775671484535,"score_spread":0.1834194236422588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}