{"id":"W1985281315","doi":"10.1139/y03-032","title":"Synthesis and degradation of endothelin-1","year":2003,"lang":"en","type":"review","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Gene isoform; Endothelins; Endothelin receptor; Chymase; Enzyme; Biochemistry; Alternative splicing; Chemistry; Endothelin 1; Phosphoramidon; Peptide; Proteolysis; Biology; Neprilysin; Cell biology; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003084696,0.0001913275,0.001499097,0.0004533026,0.00004821933,0.000002378453,0.00007243624,0.0002885184,0.0006562533],"category_scores_gemma":[0.0001063455,0.0001432465,0.0001790853,0.0001001443,0.000264427,0.00003053806,0.00000718145,0.0004221718,0.000004005242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004262451,"about_ca_system_score_gemma":0.001284144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001118496,"about_ca_topic_score_gemma":0.00004075357,"domain_scores_codex":[0.9987628,0.0003590606,0.0004822087,0.000139995,0.00004129212,0.0002146169],"domain_scores_gemma":[0.9982727,0.0006871177,0.0004715256,0.00007504842,0.00009579235,0.000397803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001046432,0.00005029037,0.0001088201,0.02308922,0.001518983,0.0003565192,0.00006703709,4.908014e-7,0.02358091,0.0001685936,0.002572426,0.9483821],"study_design_scores_gemma":[0.0008831622,0.0004776936,0.00003717569,0.001851247,0.004870258,0.003463939,0.00001253617,0.000001651006,0.007060127,0.000238523,0.9809309,0.0001727705],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007051053,0.9919158,0.000003505885,0.00006128297,0.0005111574,0.0002062399,0.00005108318,0.000001514054,0.0001983949],"genre_scores_gemma":[0.003772222,0.9953064,0.0001398659,0.0002571349,0.0002525834,0.000007633897,0.000005095534,0.00001917543,0.0002398284],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9783585,"threshold_uncertainty_score":0.7185513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03559706376898131,"score_gpt":0.3249968073624359,"score_spread":0.2893997435934546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}