{"id":"W1985282777","doi":"10.1074/jbc.m109.085084","title":"Adiponectin-induced ERK and Akt Phosphorylation Protects against Pancreatic Beta Cell Apoptosis and Increases Insulin Gene Expression and Secretion*","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":229,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Wortmannin; Protein kinase B; Adiponectin; Internal medicine; Endocrinology; PI3K/AKT/mTOR pathway; MAPK/ERK pathway; AMPK; Biology; Phosphorylation; Signal transduction; Viability assay; Beta cell; Apoptosis; Insulin; Chemistry; Protein kinase A; Cell biology; Medicine; Insulin resistance; Biochemistry; Islet","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002631679,0.0001615079,0.0003557563,0.00003755214,0.00009702009,0.00002819279,0.00004703981,0.0002245694,0.00005422528],"category_scores_gemma":[0.0007220579,0.0001060223,0.00005575454,0.00006811103,0.0001504426,0.00009065022,0.00004145439,0.0003128938,5.136358e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001181594,"about_ca_system_score_gemma":0.0000669796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001062211,"about_ca_topic_score_gemma":3.517194e-7,"domain_scores_codex":[0.9991091,0.00003643631,0.0003703513,0.0001895055,0.0001574756,0.0001371284],"domain_scores_gemma":[0.9989371,0.0001222101,0.0003359921,0.0001121218,0.000159709,0.0003328477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003307551,0.0001140449,0.02074208,0.0001544995,0.0000272786,0.000009702563,0.00005305207,3.83187e-7,0.9743434,0.000002176417,0.00002032196,0.004202277],"study_design_scores_gemma":[0.001523722,0.0001643028,0.08404262,0.0001387357,0.0001201015,0.0001970753,0.0001187269,0.00002725351,0.9131647,0.0000910665,0.0002908813,0.0001207778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967666,0.002554412,0.00002732332,0.0001338161,0.00004004055,0.000183638,0.000008291981,0.00001793397,0.0002679805],"genre_scores_gemma":[0.9961696,0.001745948,0.00149196,0.00007967574,0.0004348661,0.000008985658,0.00002504484,0.000008724253,0.00003516758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06330054,"threshold_uncertainty_score":0.4323465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01389688036892845,"score_gpt":0.2364906074080389,"score_spread":0.2225937270391104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}