{"id":"W1985295318","doi":"10.1038/cdd.2009.15","title":"Abrogation of DNA vector-based RNAi during apoptosis in mammalian cells due to caspase-mediated cleavage and inactivation of Dicer-1","year":2009,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Université Laval","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Université Laval","keywords":"Dicer; RNA interference; RNA-induced silencing complex; Cell biology; Gene silencing; Biology; Small interfering RNA; RNA silencing; Molecular biology; Ribonuclease III; Argonaute; microRNA; RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005989993,0.0006590189,0.0005931321,0.000493693,0.0002926309,0.0005335062,0.0005748188,0.0006639808,0.001168674],"category_scores_gemma":[0.0002691474,0.0004432782,0.0006519973,0.0003405107,0.0005462554,0.0005212324,0.0002754616,0.001400882,0.0004663226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008704732,"about_ca_system_score_gemma":0.0005453528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008289342,"about_ca_topic_score_gemma":0.00130179,"domain_scores_codex":[0.9994786,0.00007426771,0.00009415037,0.0001102454,0.0001398858,0.0001028395],"domain_scores_gemma":[0.9997026,0.00008506806,0.00008393119,0.00005080809,0.00003240975,0.00004512953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001032468,0.00002911445,0.00005055545,0.00004024536,0.000009998447,0.00004752647,0.00002279062,0.00006145609,0.9986162,0.0003872243,0.00003387015,0.0005977178],"study_design_scores_gemma":[0.00001608182,0.00006919335,0.0003817315,0.000001952558,0.0000106259,0.00007033427,0.000004175907,0.0005017066,0.9980982,0.00002689548,0.0008170646,0.000002149306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752268,0.002598759,0.01716786,0.0003056188,0.0001665141,0.0002204451,0.001095924,0.0004745608,0.002743491],"genre_scores_gemma":[0.9837985,0.0009188979,0.009692376,0.00008880133,0.00002546808,0.0001759298,0.001131343,0.00007158583,0.004097127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001168674,"threshold_uncertainty_score":0.006315708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00642753155950054,"score_gpt":0.2092988735402141,"score_spread":0.2028713419807135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}