{"id":"W1985295562","doi":"10.1371/journal.ppat.1003076","title":"The Polyfunctionality of Human Memory CD8+ T Cells Elicited by Acute and Chronic Virus Infections Is Not Influenced by Age","year":2012,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Immunosenescence; Immunology; CD8; Cytotoxic T cell; Biology; Granzyme B; Virus; Population; T cell; CD28; Virology; Immune system; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001599011,0.0001421731,0.0001872783,0.0002232533,0.0001186185,0.0002483461,0.00009506091,0.0001712868,0.001644605],"category_scores_gemma":[0.000344621,0.00009748599,0.0001154954,0.000132408,0.0001218595,0.0001914705,0.000155432,0.0002068155,0.0004054477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006157364,"about_ca_system_score_gemma":0.00006195896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003019589,"about_ca_topic_score_gemma":0.0002958395,"domain_scores_codex":[0.9998746,0.00001788559,0.00001235108,0.00004037247,0.00001667056,0.00003810966],"domain_scores_gemma":[0.9998373,0.00002801577,0.00004412777,0.00002831915,0.00002456223,0.00003771048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002239629,0.0001310861,0.1441435,0.00009504721,0.00004963723,0.00032068,0.0004560248,0.00009689246,0.8297285,0.00009006076,0.0001815336,0.02246731],"study_design_scores_gemma":[0.00003001809,0.002509453,0.9345014,0.00002224437,0.00006017819,0.001687283,0.0002934898,0.000197634,0.05720771,0.0001362217,0.003341978,0.00001242258],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998421,0.000694193,0.000156337,0.00001349037,0.000007537866,0.000005813224,0.0001154657,0.000003718494,0.0005825214],"genre_scores_gemma":[0.9988658,0.0002303107,0.00006578392,0.0000238759,0.000008689743,0.00001046133,0.0001730299,0.000002126033,0.0006199091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001644605,"threshold_uncertainty_score":0.005501747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01356883451910096,"score_gpt":0.236478851091855,"score_spread":0.2229100165727541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}