{"id":"W1985299376","doi":"10.1038/nbt.1646","title":"An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase","year":2010,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":148,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; McMaster University; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Center for Research Resources; Canadian Institutes of Health Research","keywords":"Allosteric regulation; Ubiquitin ligase; Cell division control protein 4; DNA ligase; Biochemistry; Ubiquitin; Binding site; Chemistry; Allosteric enzyme; Plasma protein binding; Ubiquitin-Protein Ligases; Proteasome; Druggability; Cell biology; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002876801,0.0004044154,0.0003731473,0.0002544481,0.0002943315,0.0004370718,0.000754594,0.0002710753,0.003496083],"category_scores_gemma":[0.000287421,0.0002126236,0.0002056424,0.0001844777,0.000254059,0.0001822208,0.0003283134,0.0007158987,0.0006245227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006215788,"about_ca_system_score_gemma":0.0003724362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005337142,"about_ca_topic_score_gemma":0.001132154,"domain_scores_codex":[0.999806,0.00003057403,0.00001354611,0.00003180958,0.00005839997,0.0000596051],"domain_scores_gemma":[0.9999142,0.00002129959,0.00001658056,0.00001111375,0.00001004963,0.00002683039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001056622,0.0002432209,0.0003469996,0.0001925782,0.00003504906,0.0001796566,0.00001828892,0.000756285,0.979969,0.002417775,0.001272316,0.01351226],"study_design_scores_gemma":[0.0002020709,0.0004231812,0.0007612806,0.00001183306,0.00004256518,0.0003596334,0.00001110453,0.003672942,0.9840817,0.0002253099,0.01019483,0.00001335974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9540381,0.01040351,0.01287533,0.0008900892,0.0005089109,0.0001368811,0.0003853926,0.001039637,0.0197222],"genre_scores_gemma":[0.9907309,0.001720372,0.002402116,0.0001888652,0.00005498514,0.00003559376,0.0002650569,0.00003911399,0.004562974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003496083,"threshold_uncertainty_score":0.01169556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006456891859155298,"score_gpt":0.2413562429782975,"score_spread":0.2348993511191422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}