{"id":"W1985306532","doi":"10.1074/jbc.m112.382085","title":"Dual Effect of Phosphatidyl (4,5)-Bisphosphate PIP2 on Shaker K+ Channels","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Shaker; Phosphatidylinositol 4,5-bisphosphate; Biophysics; Phosphatidylinositol; Gating; Ion channel; Chemistry; Voltage-dependent anion channel; Patch clamp; Voltage clamp; Membrane potential; Potassium channel; Voltage-gated ion channel; Biochemistry; Biology; Phosphorylation; Bacterial outer membrane; Physics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000574793,0.0001673819,0.0002754713,0.0000195355,0.0000364148,0.000007910934,0.0001176674,0.000297626,0.0002813956],"category_scores_gemma":[0.0002810485,0.0001075396,0.0002382081,0.00006556157,0.00008670306,0.000007467311,0.00004648399,0.0001614107,0.000009765762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001836371,"about_ca_system_score_gemma":0.00002007423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":5.938172e-7,"about_ca_topic_score_gemma":1.832495e-8,"domain_scores_codex":[0.9989997,0.00006097244,0.0003861257,0.0001358577,0.0001855668,0.0002318315],"domain_scores_gemma":[0.9991657,0.0000508442,0.0003744162,0.0001412836,0.0001087401,0.0001590802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001448494,0.0001964258,0.009745637,0.00004729591,0.00008986433,0.000004183182,0.00002246878,0.0001606751,0.9821189,0.00001712364,0.003242647,0.00290628],"study_design_scores_gemma":[0.0008397562,0.001159915,0.002997251,0.00002672309,0.0000185205,0.00008498709,0.00002164292,0.00001828744,0.9813512,0.00001446504,0.01334626,0.0001209978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965409,0.001258895,0.0002290701,0.00007733096,0.0007719953,0.00006533974,0.000007198635,0.000005364318,0.001043921],"genre_scores_gemma":[0.9974948,0.0001739747,0.0000626265,0.0001147136,0.001673281,0.000003137996,0.00003352299,0.00001020435,0.0004337681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01010362,"threshold_uncertainty_score":0.4385336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01692208216527871,"score_gpt":0.2582550496535616,"score_spread":0.2413329674882828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}