{"id":"W1985319029","doi":"10.1371/journal.ppat.1002963","title":"Humanized TLR4/MD-2 Mice Reveal LPS Recognition Differentially Impacts Susceptibility to Yersinia pestis and Salmonella enterica","year":2012,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Yersinia bacterium, plague, ectoparasites research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute","keywords":"Yersinia pestis; Salmonella enterica; Salmonella; Microbiology; TLR4; Yersinia; Biology; Yersinia pseudotuberculosis; Virology; Bacteria; Gene; Immunology; Immune system; Virulence; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000328412,0.0002776306,0.0002900831,0.00009857745,0.0001492113,0.00007131952,0.000196571,0.0002082267,0.0001561129],"category_scores_gemma":[0.0004238156,0.0002802653,0.0001021225,0.0001433952,0.0000949203,0.00001708294,0.0002740066,0.0001668113,0.0001753674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006230346,"about_ca_system_score_gemma":0.00005633683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000343075,"about_ca_topic_score_gemma":0.00008170788,"domain_scores_codex":[0.9978872,0.0002621241,0.0002969981,0.0005710666,0.0002598123,0.0007228317],"domain_scores_gemma":[0.9986805,0.00004986214,0.0000926443,0.0004583301,0.0001782079,0.0005403992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003393897,0.0002832571,0.08478446,0.00006343021,0.00006376636,0.000006420709,0.0002992161,1.279718e-7,0.9119529,5.735998e-7,0.001028705,0.001177716],"study_design_scores_gemma":[0.0009228492,0.0008431098,0.4437034,0.00005831534,0.0001062566,0.00007116408,0.0001067192,0.00001567691,0.5524043,0.00001412861,0.001231641,0.0005225226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979553,0.0003225302,0.0001360022,0.0001163407,0.0001477843,0.0005392772,0.0003420266,0.0000327749,0.0004079613],"genre_scores_gemma":[0.9959989,0.0001793704,0.002353283,0.0002042712,0.000442751,0.00003136043,0.0005535111,0.00004874172,0.0001877908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3595487,"threshold_uncertainty_score":0.999965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02858602344792832,"score_gpt":0.2777432511258989,"score_spread":0.2491572276779705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}