{"id":"W1985328983","doi":"10.1200/jco.2007.12.8033","title":"Quantitative Justification of the Change From 10% to 30% for Human Epidermal Growth Factor Receptor 2 Scoring in the American Society of Clinical Oncology/College of American Pathologists Guidelines: Tumor Heterogeneity in Breast Cancer and Its Implications for Tissue Microarray–Based Assessment of Outcome","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute; U.S. Public Health Service; American Society of Clinical Oncology","keywords":"Medicine; Tissue microarray; Oncology; Internal medicine; Human Epidermal Growth Factor Receptor 2; Biomarker; Clinical Oncology; Trastuzumab; Epidermal growth factor receptor; Estrogen receptor; Immunohistochemistry; Pathology; Cancer; Breast cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.07689779,0.001138996,0.001111392,0.002526156,0.001375268,0.001818364,0.002436391,0.001818151,0.001119625],"category_scores_gemma":[0.08064017,0.000517449,0.001039939,0.00203183,0.003411321,0.0008725451,0.001632712,0.002693798,0.0006168034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001504393,"about_ca_system_score_gemma":0.001305073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001500954,"about_ca_topic_score_gemma":0.003454064,"domain_scores_codex":[0.9190392,0.0526603,0.009515534,0.003305734,0.01479459,0.000684543],"domain_scores_gemma":[0.9321131,0.03543004,0.007170023,0.006415233,0.01778507,0.001086523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008312652,0.001445624,0.4210206,0.004646651,0.00265017,0.001167687,0.003473963,0.00726706,0.1369881,0.01596164,0.06601559,0.3310502],"study_design_scores_gemma":[0.00185621,0.007347455,0.6384013,0.002569764,0.001490815,0.005732921,0.002554653,0.08122478,0.1128629,0.02536068,0.1199502,0.0006483794],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5824561,0.02171028,0.3406898,0.01495785,0.007936153,0.004407784,0.002527682,0.001692044,0.02362227],"genre_scores_gemma":[0.727387,0.001072607,0.2606123,0.003835992,0.0007214203,0.002586394,0.001154074,0.0004561485,0.002174098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07689779,"threshold_uncertainty_score":0.4066792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6171535550304519,"score_gpt":0.662183900523995,"score_spread":0.04503034549354312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}