{"id":"W1985328983","doi":"10.1200/jco.2007.12.8033","title":"Quantitative Justification of the Change From 10% to 30% for Human Epidermal Growth Factor Receptor 2 Scoring in the American Society of Clinical Oncology/College of American Pathologists Guidelines: Tumor Heterogeneity in Breast Cancer and Its Implications for Tissue Microarray–Based Assessment of Outcome","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute; U.S. Public Health Service; American Society of Clinical Oncology","keywords":"Medicine; Tissue microarray; Oncology; Internal medicine; Human Epidermal Growth Factor Receptor 2; Biomarker; Clinical Oncology; Trastuzumab; Epidermal growth factor receptor; Estrogen receptor; Immunohistochemistry; Pathology; Cancer; Breast cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01342638,0.0001690615,0.002454156,0.0001756936,0.0000453604,0.000002243353,0.0004889064,0.0002017888,0.00002098974],"category_scores_gemma":[0.007849749,0.0001072376,0.0005607657,0.0005341509,0.001141649,0.00005598783,0.00009331077,0.0007084932,1.895738e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003920974,"about_ca_system_score_gemma":0.001938611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001558889,"about_ca_topic_score_gemma":0.002314375,"domain_scores_codex":[0.9922943,0.001091524,0.005563243,0.0003460679,0.0003872182,0.0003176273],"domain_scores_gemma":[0.9796314,0.01169614,0.006004799,0.0003373914,0.002138332,0.0001919048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003239344,0.001912497,0.9130435,0.0002461403,0.0001513628,0.000003794657,0.0003330205,0.00001681072,0.03752384,0.000124991,0.0007110463,0.04269364],"study_design_scores_gemma":[0.00397934,0.00966637,0.9804596,0.000218761,0.0001538929,0.000007825081,0.001154919,0.0002405945,0.002933277,0.00005426585,0.001047212,0.00008393278],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9562887,0.0001205813,0.001667251,0.03851334,0.0002353219,0.001759024,0.00140345,0.000002359055,0.000009992586],"genre_scores_gemma":[0.9534707,0.0002383955,0.04355856,0.002148185,0.0003965868,0.0001551177,0.000008642542,0.00001928003,0.000004529707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06741609,"threshold_uncertainty_score":0.9397449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6171535550304519,"score_gpt":0.662183900523995,"score_spread":0.04503034549354312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}