{"id":"W1985337146","doi":"10.1038/leu.2010.53","title":"Novel insight into stem cell mobilization-Plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex","year":2010,"lang":"en","type":"article","venue":"Leukemia","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":254,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; European Commission; National Cancer Institute; National Institutes of Health; University of Alberta","keywords":"Haematopoiesis; Progenitor cell; Bone marrow; Cell biology; Stem cell; Chemotaxis; Stromal cell; Biology; Sphingosine-1-phosphate; Immunology; Chemistry; Biochemistry; Sphingosine; Cancer research; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001309325,0.0005578304,0.0003547984,0.0003584906,0.0002839689,0.0006101281,0.0003654315,0.0004589956,0.001673351],"category_scores_gemma":[0.00005064805,0.0001736448,0.0002559132,0.0001848494,0.0004383346,0.0007815384,0.0003665565,0.0007442322,0.0003854294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003880909,"about_ca_system_score_gemma":0.0003535692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00026045,"about_ca_topic_score_gemma":0.0003237169,"domain_scores_codex":[0.9999485,0.000006283029,0.000002734401,0.00001323188,0.00001154033,0.00001766661],"domain_scores_gemma":[0.9999746,0.000003151434,0.00000524471,0.000002242802,0.000004837084,0.000009906717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002756559,0.0000643336,0.0006487473,0.000180917,0.00001103544,0.0007969943,0.00006439866,0.0002000225,0.9714687,0.01539621,0.0004061114,0.01048686],"study_design_scores_gemma":[0.0001303211,0.001014475,0.01101805,0.00004692981,0.0001075022,0.004005147,0.0004399843,0.006963953,0.9166524,0.02145589,0.0381194,0.00004586818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8489248,0.05491561,0.06935101,0.008143422,0.0007636822,0.0001114436,0.00108669,0.000613036,0.01609025],"genre_scores_gemma":[0.9548832,0.01780334,0.01791106,0.0007820902,0.0003769583,0.00006188326,0.000413153,0.00002784837,0.007740504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001673351,"threshold_uncertainty_score":0.005597889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02325974615285232,"score_gpt":0.240985131938287,"score_spread":0.2177253857854347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}