{"id":"W1985337146","doi":"10.1038/leu.2010.53","title":"Novel insight into stem cell mobilization-Plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex","year":2010,"lang":"en","type":"article","venue":"Leukemia","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":254,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; European Commission; National Cancer Institute; National Institutes of Health; University of Alberta","keywords":"Haematopoiesis; Progenitor cell; Bone marrow; Cell biology; Stem cell; Chemotaxis; Stromal cell; Biology; Sphingosine-1-phosphate; Immunology; Chemistry; Biochemistry; Sphingosine; Cancer research; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002514078,0.0002625968,0.0003606866,0.00005256849,0.000148433,0.00004816915,0.0002913557,0.0001519067,0.00002257954],"category_scores_gemma":[0.00002627412,0.0001905227,0.00007101814,0.000223838,0.00007864865,0.00002639271,0.0001351126,0.0001615767,5.900825e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000384836,"about_ca_system_score_gemma":0.0001221111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008229063,"about_ca_topic_score_gemma":0.000461135,"domain_scores_codex":[0.9984642,0.00007845339,0.0005077313,0.0004213993,0.0002896839,0.0002385149],"domain_scores_gemma":[0.9988936,0.0000990953,0.0003495591,0.0004163006,0.0001587485,0.00008265845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001744363,0.0001598526,0.003349573,0.000251718,0.00005082691,0.000001833053,0.003106978,0.0009494452,0.991734,0.00001783762,0.0000199102,0.0001836284],"study_design_scores_gemma":[0.001842124,0.00005086443,0.01507386,0.0001170201,0.00006754392,0.0000158375,0.0007171197,0.00265698,0.9790425,0.000002170353,0.0002066173,0.0002074034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978749,0.000527262,0.0003362006,0.00008618284,0.0001137965,0.0009136543,0.0001265781,0.00001037743,0.00001104446],"genre_scores_gemma":[0.9987972,0.00007466699,0.0005972935,0.0001371675,0.0001318002,0.00007985679,0.0000942262,0.00003856243,0.00004918759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01269151,"threshold_uncertainty_score":0.7769291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02325974615285232,"score_gpt":0.240985131938287,"score_spread":0.2177253857854347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}