{"id":"W1985352406","doi":"10.1006/abbi.2001.2608","title":"Soluble Recombinant Neprilysin Induces Aggrecanase-Mediated Cleavage of Aggrecan in Cartilage Explant Cultures","year":2001,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Children's Hospital; McGill University; Polytechnique Montréal","funders":"","keywords":"Aggrecanase; Aggrecan; Thiorphan; Phosphoramidon; Enkephalinase; Cartilage; Chemistry; Neprilysin; Chondrocyte; Cell biology; Glycosaminoglycan; Biochemistry; Enzyme; In vitro; Anatomy; Biology; Osteoarthritis; Medicine; Articular cartilage; Enkephalin; Pathology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005337679,0.0006192331,0.0006847982,0.0005699255,0.0003006617,0.0004698564,0.0004570495,0.0004227754,0.001410979],"category_scores_gemma":[0.0003196784,0.0003805858,0.0007848035,0.0003525068,0.0004154152,0.0003051435,0.0003823828,0.001396329,0.0008900822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006131504,"about_ca_system_score_gemma":0.0004029584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00154445,"about_ca_topic_score_gemma":0.00306791,"domain_scores_codex":[0.9995075,0.00008818266,0.00006550911,0.00007277363,0.0001278595,0.0001381459],"domain_scores_gemma":[0.9992682,0.0002766044,0.00008371505,0.0001255692,0.00008136366,0.0001644814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001494155,0.00003184296,0.00005481645,0.00001705642,0.000005044736,0.00008438491,0.0000191715,0.0000293828,0.9993187,0.00003527341,0.00001346199,0.0002414649],"study_design_scores_gemma":[0.000008124392,0.0001747583,0.0009984963,0.000002873131,0.00001238913,0.0001157541,0.00001773292,0.0003967958,0.9979277,0.00001377273,0.0003296449,0.000002037069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897865,0.001810684,0.005139407,0.00009219051,0.00007736826,0.00006991873,0.0005200425,0.00008774617,0.0024161],"genre_scores_gemma":[0.9839869,0.0009645212,0.005748251,0.00007512954,0.00003903018,0.00006563998,0.001244843,0.00003853204,0.0078372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00154445,"threshold_uncertainty_score":0.004720211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01120279517016291,"score_gpt":0.2466527182904336,"score_spread":0.2354499231202707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}