{"id":"W1985355304","doi":"10.1371/journal.ppat.1003439","title":"An Acidic Microenvironment Increases NK Cell Killing of Cryptococcus neoformans and Cryptococcus gattii by Enhancing Perforin Degranulation","year":2013,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Cryptococcus gattii; Cryptococcus neoformans; Degranulation; Perforin; Biology; Cryptococcus; Microbiology; Cryptococcosis; Immune system; Immunology; CD8; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000110094,0.0001975096,0.000326591,0.0001005893,0.0002134191,0.00002135607,0.00004340333,0.00008128842,0.0002779153],"category_scores_gemma":[0.0000265306,0.0001670509,0.00007107968,0.00009831983,0.0001190439,0.0001708775,0.00004176496,0.0001345487,0.00004719793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006064762,"about_ca_system_score_gemma":0.00001894933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002967725,"about_ca_topic_score_gemma":0.0000216548,"domain_scores_codex":[0.9988725,0.00004269052,0.0003481506,0.0002684013,0.0001838002,0.0002844446],"domain_scores_gemma":[0.9993302,0.00006409841,0.0001138682,0.0002478101,0.0000767799,0.0001672595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002020731,0.0004203889,0.1350787,0.0002099689,0.00003924662,0.000002632839,0.000530313,0.00001622374,0.8620917,0.000006330503,0.0001279227,0.001456353],"study_design_scores_gemma":[0.001305167,0.001237282,0.166272,0.0002660582,0.0003497049,0.00001873465,0.001931047,0.003522255,0.8242338,0.00004522058,0.0004890729,0.0003297024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967098,0.001062799,0.0007865941,0.00005005791,0.00004073777,0.0008605435,0.00004340695,0.00004474288,0.0004012751],"genre_scores_gemma":[0.9967062,0.0008050923,0.001992092,0.00007349534,0.0000803095,0.0001649237,0.0000562205,0.0000262532,0.00009543514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03785796,"threshold_uncertainty_score":0.6812138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009921872302218646,"score_gpt":0.2220066140854874,"score_spread":0.2120847417832688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}