{"id":"W1985355304","doi":"10.1371/journal.ppat.1003439","title":"An Acidic Microenvironment Increases NK Cell Killing of Cryptococcus neoformans and Cryptococcus gattii by Enhancing Perforin Degranulation","year":2013,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Cryptococcus gattii; Cryptococcus neoformans; Degranulation; Perforin; Biology; Cryptococcus; Microbiology; Cryptococcosis; Immune system; Immunology; CD8; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005109484,0.0002446269,0.0001870502,0.0001071793,0.00009618099,0.0001943914,0.00008365911,0.0001588427,0.001251975],"category_scores_gemma":[0.00007902538,0.0001014583,0.000109296,0.00006866773,0.0001683672,0.0001483961,0.0002163531,0.0002815357,0.000150194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002025178,"about_ca_system_score_gemma":0.0001671061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007413841,"about_ca_topic_score_gemma":0.0008688743,"domain_scores_codex":[0.9999328,0.000009940466,0.000006261498,0.00001293419,0.00001268162,0.0000253806],"domain_scores_gemma":[0.9999548,0.00000737154,0.00001062557,0.000003275127,0.000003458822,0.00002043072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002537326,0.00002610732,0.0001820638,0.00002130873,0.000001230839,0.00006199664,0.00001021415,0.00003843388,0.9986615,0.00001748784,0.00001583618,0.0007101645],"study_design_scores_gemma":[0.00005370018,0.001033041,0.0168016,0.000009051116,0.00001470094,0.0005924678,0.00006721516,0.0007217495,0.9790986,0.0000441257,0.001557691,0.000006015089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986643,0.0004106414,0.000220656,0.00003189181,0.00000943327,0.00001004187,0.00005756001,0.00001494216,0.0005806468],"genre_scores_gemma":[0.9980807,0.0002563367,0.0005854705,0.00002849071,0.000004911989,0.0000123312,0.0001019907,0.000004630583,0.00092521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001251975,"threshold_uncertainty_score":0.00418824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009921872302218646,"score_gpt":0.2220066140854874,"score_spread":0.2120847417832688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}