{"id":"W1985392788","doi":"10.1167/iovs.06-0062","title":"Human Trabecular Meshwork Cells Express Functional Serotonin-2A (5HT<sub>2A</sub>) Receptors: Role in IOP Reduction","year":2006,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Waterloo","keywords":"Receptor; 5-HT receptor; Serotonin; Trabecular meshwork; Agonist; 5-HT2 receptor; Chemistry; 5-HT2A receptor; Tryptamine; Endocrinology; Internal medicine; Receptor antagonist; Pharmacology; Antagonist; Intraocular pressure; Biology; Medicine; Biochemistry; Ophthalmology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.0007606133,0.0003485719,0.0004395631,0.0004331675,0.0004970847,0.00004710181,0.0002913637,0.0002609999,0.0002376916],"category_scores_gemma":[0.0001221703,0.000317727,0.0001227586,0.001569911,0.004637846,0.0003621427,0.0001126605,0.0005663235,0.0001349703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002704497,"about_ca_system_score_gemma":0.0004049591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004045381,"about_ca_topic_score_gemma":0.00001894989,"domain_scores_codex":[0.9967384,0.0002612636,0.000524441,0.0009742695,0.000729633,0.0007719906],"domain_scores_gemma":[0.9988532,0.0000543222,0.0002203456,0.000291756,0.0002489691,0.000331423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006992445,0.000393131,0.05891844,0.00002087925,0.00001278392,0.0001463685,0.0004216311,0.0001066968,0.9390925,0.0002811794,0.0004664716,0.00007004446],"study_design_scores_gemma":[0.0006337659,0.0006473804,0.3129134,0.000129567,0.00002503818,0.0004144472,0.0006257741,0.000118162,0.6795939,0.004540046,0.0001159273,0.0002425469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937011,0.0001902309,0.000004845564,0.0006093716,0.0005912937,0.0007085236,0.000002857097,0.00006036364,0.004131388],"genre_scores_gemma":[0.9980776,0.000003711771,0.0005579374,0.0001346331,0.0002352349,0.0001282233,0.00003178332,0.0000292596,0.0008015873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2594986,"threshold_uncertainty_score":0.9999275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01935925028406615,"score_gpt":0.2904166427894594,"score_spread":0.2710573925053932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}