{"id":"W1985392788","doi":"10.1167/iovs.06-0062","title":"Human Trabecular Meshwork Cells Express Functional Serotonin-2A (5HT<sub>2A</sub>) Receptors: Role in IOP Reduction","year":2006,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Waterloo","keywords":"Receptor; 5-HT receptor; Serotonin; Trabecular meshwork; Agonist; 5-HT2 receptor; Chemistry; 5-HT2A receptor; Tryptamine; Endocrinology; Internal medicine; Receptor antagonist; Pharmacology; Antagonist; Intraocular pressure; Biology; Medicine; Biochemistry; Ophthalmology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000114744,0.0001469864,0.0001929834,0.0001235805,0.0001488548,0.0002212231,0.00009658364,0.0002218839,0.001578212],"category_scores_gemma":[0.000185327,0.00009490322,0.0001677714,0.0002055689,0.0001493293,0.0001091986,0.00009817164,0.0001841961,0.0005693864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001621724,"about_ca_system_score_gemma":0.0001560042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002235417,"about_ca_topic_score_gemma":0.003035455,"domain_scores_codex":[0.9998868,0.00001792999,0.00001188942,0.0000179359,0.00003845723,0.00002697052],"domain_scores_gemma":[0.9999131,0.00002348572,0.00001935025,0.00001481158,0.00001468761,0.00001465866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002389422,0.00003019966,0.003835802,0.00003451134,0.000006704808,0.0001211546,0.00003248617,0.00002235701,0.9933994,0.00003249075,0.00007189543,0.002174062],"study_design_scores_gemma":[0.0001996204,0.002380915,0.1766181,0.00002252745,0.0001263128,0.003566177,0.000403184,0.001488975,0.8092167,0.0001421379,0.005819715,0.00001572395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953139,0.001022032,0.001878663,0.00006864217,0.00001771826,0.00003126599,0.0003067098,0.00003248124,0.001328565],"genre_scores_gemma":[0.9958228,0.0005264597,0.002165278,0.00006429122,0.00001965997,0.00004015012,0.0005093846,0.000007459871,0.0008445526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002235417,"threshold_uncertainty_score":0.00527966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01935925028406615,"score_gpt":0.2904166427894594,"score_spread":0.2710573925053932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}