{"id":"W1985442980","doi":"10.1016/j.bmcl.2004.06.035","title":"Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1H-indol-5-yl)-ethyl acrylamides","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Chemistry; Benzofuran; Acrylamide; Stereochemistry; Potency; Enantiomer; Chemical synthesis; In vitro; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004696223,0.0005099708,0.0004251297,0.0002539193,0.0002632617,0.0002918939,0.0004500769,0.000331655,0.002166858],"category_scores_gemma":[0.000422928,0.0003070954,0.0003081888,0.0002638899,0.0002599997,0.0004199388,0.0002079095,0.0005480447,0.0006310118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003461439,"about_ca_system_score_gemma":0.0004063832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007888963,"about_ca_topic_score_gemma":0.0009021741,"domain_scores_codex":[0.9997637,0.00004014041,0.00003812441,0.00005433536,0.00004673038,0.00005700078],"domain_scores_gemma":[0.9996992,0.00006651421,0.00007236359,0.00004319149,0.00004869343,0.00007002577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003221699,0.00005568271,0.00004018563,0.00006242291,0.000010068,0.00006839757,0.00002951204,0.0002201345,0.9973224,0.0002363799,0.00007013271,0.001562454],"study_design_scores_gemma":[0.0001070602,0.0004483072,0.0005862056,0.000005703599,0.00001340343,0.00009047698,0.000009607634,0.0003889013,0.9965852,0.00003075674,0.001723627,0.00001065316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860905,0.001878864,0.007354753,0.0001785291,0.00008331365,0.000172906,0.001189397,0.0001530087,0.002898616],"genre_scores_gemma":[0.9817571,0.001434768,0.009221314,0.0001095421,0.00005957429,0.0002137529,0.002294515,0.00008487586,0.004824468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002166858,"threshold_uncertainty_score":0.007248878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008789118257350226,"score_gpt":0.2194689971747957,"score_spread":0.2106798789174454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}