{"id":"W1985443358","doi":"10.1007/s10863-005-9496-6","title":"New Insights into the Drug Binding, Transport and Lipid Flippase Activities of the P-Glycoprotein Multidrug Transporter","year":2005,"lang":"en","type":"review","venue":"Journal of Bioenergetics and Biomembranes","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"ATP-binding cassette transporter; Flippase; Biochemistry; Transporter; Efflux; P-glycoprotein; Binding site; Plasma protein binding; Glycoprotein; Förster resonance energy transfer; Chemistry; Lipid bilayer; Transport protein; Membrane transport protein; Biology; Multiple drug resistance; Membrane; Fluorescence; Gene; Phospholipid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001087511,0.001128754,0.002244852,0.001972043,0.0003187398,0.001648607,0.001245852,0.001362818,0.002032204],"category_scores_gemma":[0.0007537575,0.0004815347,0.00053315,0.002405303,0.0009573062,0.003234023,0.0007645848,0.002353193,0.001626317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009361472,"about_ca_system_score_gemma":0.001116866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000988757,"about_ca_topic_score_gemma":0.002042684,"domain_scores_codex":[0.9997786,0.00003061649,0.00003268287,0.0000425428,0.00009317164,0.00002248259],"domain_scores_gemma":[0.9995981,0.0001946656,0.00005103674,0.00001484131,0.0001037656,0.00003759138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001702454,0.0000898244,0.000200708,0.01154925,0.0001086177,0.0004916419,0.0001019921,0.000682071,0.01171873,0.007855724,0.01438671,0.9526445],"study_design_scores_gemma":[0.00005193682,0.0001640957,0.001022228,0.001644077,0.0001701292,0.002316232,0.0001044887,0.0003218629,0.002825096,0.005035995,0.9862987,0.00004499376],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000184198,0.9987446,0.0002894539,0.0002033548,0.00009644429,0.000002095469,0.00000836094,0.000004874141,0.0004665658],"genre_scores_gemma":[0.0006855613,0.9982863,0.0003443547,0.0001319498,0.0001336592,0.000002905761,0.00002123043,8.855473e-7,0.0003931458],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002244852,"threshold_uncertainty_score":0.006798327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01367137075617644,"score_gpt":0.2623143192273922,"score_spread":0.2486429484712158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}