{"id":"W1985516890","doi":"10.1073/pnas.1008247107","title":"Human RORγt <sup>+</sup> T <sub>H</sub> 17 cells preferentially differentiate from naive FOXP3 <sup>+</sup> Treg in the presence of lineage-specific polarizing factors","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Regional Development Fund; Institute of Cancer Research; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Ludwig Institute for Cancer Research; Conseil Régional des Pays de la Loire; Cancer Research Institute","keywords":"FOXP3; Priming (agriculture); RAR-related orphan receptor gamma; Interleukin 17; Proinflammatory cytokine; Biology; T cell; Immunology; Population; Cell biology; Cytokine; Molecular biology; Inflammation; Immune system; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001219407,0.0003179378,0.000505685,0.000376158,0.0005315746,0.00005052201,0.002597017,0.0005333873,0.0001360823],"category_scores_gemma":[0.0002621997,0.0001955613,0.000235244,0.000680881,0.002629018,0.0004788665,0.0004465574,0.001247988,0.0000122482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002818757,"about_ca_system_score_gemma":0.0000629007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00011746,"about_ca_topic_score_gemma":0.000004512367,"domain_scores_codex":[0.9974717,0.0000762499,0.0008749127,0.0005981806,0.0004940822,0.0004849016],"domain_scores_gemma":[0.9981222,0.000578068,0.0009004334,0.00006835846,0.0003031358,0.00002780656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005250043,0.0002821218,0.008873856,0.00003068953,0.00008275925,2.908931e-8,0.003254771,0.0001497277,0.9816153,0.004720621,0.0007481708,0.0001894658],"study_design_scores_gemma":[0.0006832713,0.0001243793,0.03537782,0.0001024737,0.00004369501,0.00000440964,0.00158248,0.0002049119,0.9552985,0.005990474,0.0003950391,0.0001925751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974529,0.0004058804,0.000001944764,0.0005673041,0.0001259703,0.0004134178,0.0001168471,0.0000232288,0.0008925176],"genre_scores_gemma":[0.9993585,0.00008993234,0.00009785587,0.00008259297,0.00009432039,0.00001782998,0.000009481298,0.00001290237,0.00023659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02650397,"threshold_uncertainty_score":0.9686728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03136319789601672,"score_gpt":0.255069759616301,"score_spread":0.2237065617202842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}