{"id":"W1985516890","doi":"10.1073/pnas.1008247107","title":"Human RORγt <sup>+</sup> T <sub>H</sub> 17 cells preferentially differentiate from naive FOXP3 <sup>+</sup> Treg in the presence of lineage-specific polarizing factors","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Regional Development Fund; Institute of Cancer Research; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Ludwig Institute for Cancer Research; Conseil Régional des Pays de la Loire; Cancer Research Institute","keywords":"FOXP3; Priming (agriculture); RAR-related orphan receptor gamma; Interleukin 17; Proinflammatory cytokine; Biology; T cell; Immunology; Population; Cell biology; Cytokine; Molecular biology; Inflammation; Immune system; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001038287,0.0002692911,0.0001685303,0.0001694796,0.00009055432,0.0002686664,0.00008442639,0.0001348291,0.002209618],"category_scores_gemma":[0.00006664429,0.0001023709,0.0001917929,0.0001314474,0.0001296614,0.00009897164,0.0001114881,0.0003808147,0.001176999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008831917,"about_ca_system_score_gemma":0.0001061378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002603202,"about_ca_topic_score_gemma":0.0004276384,"domain_scores_codex":[0.9998693,0.00001896119,0.00001169322,0.00002669904,0.00002988737,0.00004332947],"domain_scores_gemma":[0.9999455,0.00001018073,0.00001373814,0.00001148373,0.000006393705,0.00001271492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007082364,0.000009436122,0.00036424,0.00001759133,0.000003161078,0.00005300886,0.00001691157,0.00001645043,0.9983128,0.00002618544,0.00003295893,0.001076307],"study_design_scores_gemma":[0.00003456433,0.0005839113,0.01992657,0.00001277843,0.00003652428,0.001561018,0.00008513881,0.000396225,0.9689354,0.00005714695,0.008365304,0.000005441766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918246,0.001747459,0.003865629,0.00006597606,0.00002466159,0.00004609008,0.0006635317,0.00007787548,0.001684171],"genre_scores_gemma":[0.9880932,0.001504492,0.003132005,0.0001086979,0.00004813827,0.0001014959,0.002814948,0.00003877924,0.004158224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002209618,"threshold_uncertainty_score":0.00739187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03136319789601672,"score_gpt":0.255069759616301,"score_spread":0.2237065617202842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}