{"id":"W1985537536","doi":"10.1021/ja802008q","title":"Bifunctional CD22 Ligands Use Multimeric Immunoglobulins as Protein Scaffolds in Assembly of Immune Complexes on B Cells","year":2008,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; University of California, San Diego","keywords":"CD22; Chemistry; Avidity; Ligand (biochemistry); Antibody; Lectin; SIGLEC; Antigen; Biochemistry; Cell; Receptor; CD19; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001695572,0.0003028126,0.0001259483,0.000151233,0.0001725095,0.0003376048,0.0001665016,0.0002549612,0.000617413],"category_scores_gemma":[0.0001356871,0.0001180863,0.0001261815,0.0001210908,0.0002229588,0.0002315422,0.0003358712,0.0002901788,0.0003252659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003791084,"about_ca_system_score_gemma":0.000112062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002465051,"about_ca_topic_score_gemma":0.0004509017,"domain_scores_codex":[0.9998828,0.00003414511,0.000007231006,0.00002211635,0.00002768583,0.00002598629],"domain_scores_gemma":[0.9999511,0.00001063165,0.00001075592,0.000008682849,0.000005255712,0.00001364116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000270062,0.00001206082,0.00009453874,0.00001844507,0.00000229201,0.0000286833,0.00001337673,0.0001181698,0.9972711,0.000465515,0.00002919769,0.001919696],"study_design_scores_gemma":[0.00001008467,0.00009772777,0.0004153236,0.00000333724,0.000005951366,0.0001163458,0.00001095341,0.0009922616,0.9949036,0.00007116128,0.003369543,0.000003698358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98779,0.0009299709,0.009489459,0.00009155204,0.00001642825,0.00002998964,0.0000566199,0.00008977406,0.001506223],"genre_scores_gemma":[0.9836626,0.0006186119,0.01352841,0.00007237249,0.000006846357,0.00003556954,0.0001424302,0.00002926328,0.001903848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000617413,"threshold_uncertainty_score":0.002750695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01690205123710465,"score_gpt":0.2699950130500882,"score_spread":0.2530929618129835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}