{"id":"W1985542799","doi":"10.4161/cc.6.16.4526","title":"Regulation of p27<sup>Kip1</sup>by miRNA 221/222 in Glioblastoma","year":2007,"lang":"en","type":"letter","venue":"Cell Cycle","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":262,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Dicer; microRNA; Biology; Downregulation and upregulation; Untranslated region; Gene silencing; Three prime untranslated region; RNA interference; Cell cycle; Gene expression; Molecular biology; Reporter gene; Cell biology; Gene; Cancer research; Messenger RNA; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000175756,0.0003036946,0.0002900501,0.0001754106,0.000033106,0.00001608251,0.0002873576,0.001092378,0.0001711337],"category_scores_gemma":[0.00002827069,0.000346098,0.0001764334,0.0001690339,0.0001062394,0.000005502413,0.0001081761,0.0003580913,0.00004089158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007038761,"about_ca_system_score_gemma":0.00007849268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004150479,"about_ca_topic_score_gemma":0.00001164131,"domain_scores_codex":[0.9982222,0.00009768701,0.0004772907,0.0005471708,0.0002825836,0.0003731083],"domain_scores_gemma":[0.9988745,0.00002080085,0.0002985811,0.0006475736,0.00009804893,0.00006043963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006136622,0.00005388321,0.0003098059,0.0001701311,0.00002013279,0.00001179616,0.00002360247,0.0004895648,0.4254265,7.504308e-7,0.5730861,0.0003464359],"study_design_scores_gemma":[0.0006059468,0.00009616636,0.001883538,0.00006728522,0.00003494453,0.000006482921,0.000009386188,0.0003566413,0.5074351,0.00006472269,0.4890784,0.0003614125],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869339,0.002371999,0.0004040391,0.0063095,0.0001676081,0.0005513312,0.000186744,0.00002504187,0.003049857],"genre_scores_gemma":[0.962761,0.00009802792,0.00037407,0.02623321,0.001859937,0.0000310361,0.00383009,0.0001463012,0.004666296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0840077,"threshold_uncertainty_score":0.9998991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004550402528797214,"score_gpt":0.2143425201951637,"score_spread":0.2097921176663665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}