{"id":"W1985577080","doi":"10.1182/blood-2012-06-435875","title":"Methemoglobinemia and ascorbate deficiency in hemoglobin E β thalassemia: metabolic and clinical implications","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Medical Research Council; Wellcome Trust; March of Dimes Foundation","keywords":"Methemoglobin; Thalassemia; Methemoglobinemia; Hemoglobin; Haptoglobin; Medicine; Internal medicine; Ascorbic acid; Endocrinology; Population; Anemia; Hemolytic anemia; Oxygen–haemoglobin dissociation curve; Hemoglobinopathy; Immunology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001809172,0.0003397328,0.0002089187,0.0004825692,0.00025232,0.0002621031,0.0002053955,0.0006783686,0.001221435],"category_scores_gemma":[0.0006276377,0.0001164931,0.00008070516,0.0003649136,0.0006171506,0.0002912787,0.0001981239,0.0004398588,0.0001424533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001349871,"about_ca_system_score_gemma":0.0001425085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003599445,"about_ca_topic_score_gemma":0.0003168879,"domain_scores_codex":[0.9999167,0.00003476987,0.000008651157,0.00001473552,0.00001286266,0.00001227652],"domain_scores_gemma":[0.9997906,0.0001074714,0.00004880882,0.000008330319,0.00000959413,0.00003518378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00273661,0.0004802427,0.553432,0.0004634548,0.00009619474,0.3067201,0.0009908143,0.0008035605,0.03817979,0.003874569,0.001938099,0.09028444],"study_design_scores_gemma":[0.00008804302,0.001439536,0.4529291,0.0001040792,0.0001188911,0.5227269,0.0008409297,0.002143543,0.007395578,0.003857972,0.00832224,0.00003310568],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821649,0.01148543,0.0009945646,0.001772979,0.00004545177,0.000016719,0.00005299412,0.00002921114,0.003437822],"genre_scores_gemma":[0.9970832,0.001654128,0.0003772285,0.0001651224,0.0001224516,0.000005178117,0.00002863974,0.000003523593,0.0005603986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001221435,"threshold_uncertainty_score":0.004086137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01463556915463018,"score_gpt":0.2922266558339174,"score_spread":0.2775910866792873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}