{"id":"W1985585046","doi":"10.1038/nature05175","title":"Molecular architecture and assembly of the DDB1–CUL4A ubiquitin ligase machinery","year":2006,"lang":"en","type":"article","venue":"Nature","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":667,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Cullin; DDB1; Ubiquitin ligase; Ubiquitin; Ubiquitin-Protein Ligases; Biology; Cell biology; DNA ligase; COP9 signalosome; Cell division control protein 4; Signal transducing adaptor protein; Biochemistry; DNA; Enzyme; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002355217,0.0003167393,0.0003057664,0.0004598138,0.0007450766,0.001662828,0.0006171147,0.0005958867,0.001467948],"category_scores_gemma":[0.0002917111,0.000687546,0.0003084574,0.0003166029,0.0004664439,0.001137932,0.0004229818,0.0007239877,0.001408282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002021675,"about_ca_system_score_gemma":0.0006511121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001481461,"about_ca_topic_score_gemma":0.001376088,"domain_scores_codex":[0.999878,0.00001192108,0.000009853619,0.00003787837,0.00002924349,0.00003308988],"domain_scores_gemma":[0.9998839,0.00001212929,0.00002474687,0.00002232834,0.00001874309,0.00003813688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002630727,0.00004171785,0.002033087,0.0001632137,0.00002374567,0.0004566572,0.0001060003,0.005933259,0.9417695,0.03275201,0.001764036,0.01469366],"study_design_scores_gemma":[0.00003124903,0.0001238823,0.01476853,0.00003526596,0.00003568748,0.00102055,0.000137098,0.04114562,0.8882579,0.01371989,0.04066806,0.00005629152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9005323,0.01303301,0.06465989,0.002173993,0.0002366313,0.00006519281,0.0008318389,0.001799069,0.01666812],"genre_scores_gemma":[0.9750108,0.002719344,0.01388799,0.0001221882,0.00004506622,0.00002863365,0.0009333642,0.0000738762,0.007178679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002021675,"threshold_uncertainty_score":0.01466829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003238703601711568,"score_gpt":0.2187973742993527,"score_spread":0.2155586706976411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}