{"id":"W1985585046","doi":"10.1038/nature05175","title":"Molecular architecture and assembly of the DDB1–CUL4A ubiquitin ligase machinery","year":2006,"lang":"en","type":"article","venue":"Nature","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":667,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Cullin; DDB1; Ubiquitin ligase; Ubiquitin; Ubiquitin-Protein Ligases; Biology; Cell biology; DNA ligase; COP9 signalosome; Cell division control protein 4; Signal transducing adaptor protein; Biochemistry; DNA; Enzyme; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001215734,0.0001458882,0.0001180981,0.00002554911,0.00005991405,0.00001540255,0.0002072534,0.0007384133,0.000006994331],"category_scores_gemma":[0.00007009377,0.000100381,0.0001057126,0.00009146939,0.00008220842,0.000001566151,0.0001486443,0.0007019584,9.649049e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003968442,"about_ca_system_score_gemma":0.00003993436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002323631,"about_ca_topic_score_gemma":0.00003588414,"domain_scores_codex":[0.9992213,0.0000730807,0.000132119,0.0002442689,0.0001544791,0.000174775],"domain_scores_gemma":[0.999487,0.00001067147,0.00007828741,0.0003320603,0.00005252607,0.00003947469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002946953,0.00002861801,0.001009176,0.00003641978,0.00001648173,0.00000517632,0.00001543702,0.0000600442,0.9941677,0.001286518,0.001939434,0.00140557],"study_design_scores_gemma":[0.0002805466,0.00006424139,0.00389464,0.00002339857,0.00001572386,0.00004200327,0.000008485666,0.00001435367,0.9679515,0.0008718908,0.02670737,0.0001257856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876128,0.005792907,0.0001333257,0.000856586,0.0000974772,0.0001850041,0.00006064138,0.00001045196,0.005250807],"genre_scores_gemma":[0.997649,0.00002437379,0.000453471,0.001149225,0.0002116766,0.000009525449,0.00005217995,0.00001956189,0.0004309765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0262161,"threshold_uncertainty_score":0.569532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003238703601711568,"score_gpt":0.2187973742993527,"score_spread":0.2155586706976411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}