{"id":"W1985589959","doi":"10.1111/j.1432-1033.2004.04078.x","title":"Single phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2 confers high‐affinity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ‐RGS3 protein","year":2004,"lang":"en","type":"article","venue":"European Journal of Biochemistry","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"National Research Council Canada; Government of Canada; Genomic Health","keywords":"PDZ domain; SH2 domain; Phosphopeptide; Phosphorylation; Ephrin; Tyrosine phosphorylation; GRB2; Biology; Cell biology; Phosphotyrosine-binding domain; Binding site; Signal transducing adaptor protein; Biochemistry; Chemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002022761,0.0001431562,0.0002511393,0.00005413375,0.0001359439,0.00002443629,0.000509131,0.00003157663,0.00001077524],"category_scores_gemma":[0.0005377154,0.00007261711,0.0001079108,0.0003455316,0.0007617693,0.00007444712,0.0001266491,0.0003325548,4.987871e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002977101,"about_ca_system_score_gemma":0.0001118964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001418172,"about_ca_topic_score_gemma":0.000002264214,"domain_scores_codex":[0.9979157,0.00054821,0.0006967206,0.0001751446,0.0005124318,0.000151808],"domain_scores_gemma":[0.9982915,0.0003972804,0.0009435109,0.0002434271,0.00008043194,0.00004385679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005537635,0.00008523793,0.0005966898,0.00005021372,0.00001210108,0.00001017664,0.001028312,0.0004315174,0.9963309,0.0006633817,0.00002573754,0.0002120301],"study_design_scores_gemma":[0.001712457,0.000228701,0.006097252,0.0003469106,0.00002051704,0.0001024117,0.001068946,0.000007731121,0.989564,0.0006692031,0.0001080872,0.00007379894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973633,0.0001816292,0.0001840166,0.001415652,0.00005929187,0.0002417513,0.00002084351,0.000002330072,0.0005311815],"genre_scores_gemma":[0.9994599,0.00003547922,0.0002207146,0.0001900193,0.00005536165,0.000001672496,3.777104e-7,0.00001329854,0.0000232121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006766855,"threshold_uncertainty_score":0.296124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01653209377770416,"score_gpt":0.2077874111710825,"score_spread":0.1912553173933784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}