{"id":"W1985602021","doi":"10.1128/aac.00170-11","title":"Mechanism of Action and Limited Cross-Resistance of New Lipopeptide MX-2401","year":2011,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"iCo Therapeutics (Canada); University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Rheinische Friedrich-Wilhelms-Universität Bonn; Deutsche Forschungsgemeinschaft; Michael Smith Health Research BC","keywords":"Daptomycin; Lipopeptide; Depolarization; Lipid II; Biophysics; Mechanism of action; Biochemistry; Biology; Chemistry; In vitro; Peptidoglycan; Cell wall; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008910504,0.0002051815,0.0003849272,0.00008154654,0.0001099178,0.0000150036,0.0001267597,0.0002047727,0.0005133605],"category_scores_gemma":[0.000007405931,0.0001844975,0.0000906916,0.00008510095,0.00037612,0.0001642271,0.00005708695,0.0001225757,0.0000080212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007454322,"about_ca_system_score_gemma":0.00003110157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006907312,"about_ca_topic_score_gemma":0.00006266064,"domain_scores_codex":[0.9990849,0.00003401558,0.0003376052,0.0002750629,0.00002874863,0.0002396713],"domain_scores_gemma":[0.9994435,0.00002274614,0.0002659519,0.0001769657,0.00006007462,0.00003076546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006727143,0.00019418,0.006402995,0.0001138971,0.0002269862,0.000001523438,0.001965557,2.204037e-7,0.9710836,0.001500527,0.01265367,0.005184131],"study_design_scores_gemma":[0.001882069,0.000151094,0.03355316,0.0001183159,0.00004032931,0.00002186076,0.0001588174,0.000001083754,0.9537274,0.0005513507,0.009585381,0.0002091969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981274,0.0001864998,0.0002976638,0.0001740132,0.0002153047,0.0001689776,0.00004735416,0.00002709399,0.000755664],"genre_scores_gemma":[0.9895296,0.002336947,0.0008598104,0.0007393896,0.00003006678,0.000001207161,0.0000193898,0.00002494395,0.006458632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02715017,"threshold_uncertainty_score":0.752359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03366965513252532,"score_gpt":0.2578360791306795,"score_spread":0.2241664239981541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}