{"id":"W1985602021","doi":"10.1128/aac.00170-11","title":"Mechanism of Action and Limited Cross-Resistance of New Lipopeptide MX-2401","year":2011,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"iCo Therapeutics (Canada); University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Rheinische Friedrich-Wilhelms-Universität Bonn; Deutsche Forschungsgemeinschaft; Michael Smith Health Research BC","keywords":"Daptomycin; Lipopeptide; Depolarization; Lipid II; Biophysics; Mechanism of action; Biochemistry; Biology; Chemistry; In vitro; Peptidoglycan; Cell wall; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001694612,0.0002867999,0.0002810235,0.00015311,0.00009792183,0.0002662062,0.0002663956,0.0003838946,0.0008498901],"category_scores_gemma":[0.0001316678,0.0001127274,0.0002918956,0.00007193075,0.0001796883,0.0002527507,0.0002069643,0.0005457753,0.0003321708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002564261,"about_ca_system_score_gemma":0.00009555997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001110533,"about_ca_topic_score_gemma":0.00006187672,"domain_scores_codex":[0.9998873,0.00002732851,0.00001089357,0.00002452215,0.00002649377,0.00002353419],"domain_scores_gemma":[0.9999237,0.00001576701,0.00002580945,0.000008407245,0.000007910056,0.00001840438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001743827,0.00004525614,0.0001352786,0.00007225306,0.000006865281,0.0001342783,0.00001614958,0.0001508453,0.9970611,0.0002201566,0.00002549645,0.00195785],"study_design_scores_gemma":[0.00008683213,0.001561969,0.002948535,0.00001327713,0.00001919222,0.001310468,0.00002005118,0.001281467,0.988974,0.00009303281,0.003683597,0.000007469221],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912549,0.00446512,0.002128575,0.0000952535,0.00002061649,0.00009200961,0.000200074,0.00004043891,0.00170299],"genre_scores_gemma":[0.9949602,0.001478551,0.001592464,0.00006972919,0.00001004722,0.00009421233,0.0002713112,0.000009338457,0.001514021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008498901,"threshold_uncertainty_score":0.002843201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03366965513252532,"score_gpt":0.2578360791306795,"score_spread":0.2241664239981541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}