{"id":"W1985632884","doi":"10.1139/o07-009","title":"Suppression of <i>DPYD</i> expression in RKO Cells via DNA methylation in the regulatory region of the <i>DPYD</i> promoter: a potentially important epigenetic mechanism regulating <i>DPYD</i> expression","year":2007,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Cancer Institute","keywords":"DPYD; Dihydropyrimidine dehydrogenase; Trichostatin A; DNA methylation; Methylation; Epigenetics; Bisulfite sequencing; Transactivation; Molecular biology; Cancer research; Chemistry; Biology; Gene expression; Histone; Fluorouracil; Histone deacetylase; Biochemistry; Gene; Genetics; Pharmacogenetics; Cancer; Thymidylate synthase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009140322,0.0001926977,0.0002167246,0.0001027533,0.00007824053,0.0001674629,0.0001078961,0.0001489264,0.0006634779],"category_scores_gemma":[0.0001115402,0.000113521,0.0001831414,0.00008919772,0.0001753248,0.00008259658,0.0001070508,0.0002698885,0.0002560797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001431587,"about_ca_system_score_gemma":0.00009343104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006706055,"about_ca_topic_score_gemma":0.0006037902,"domain_scores_codex":[0.9999105,0.00001427332,0.00001277527,0.00002359468,0.00001897415,0.00001997792],"domain_scores_gemma":[0.9999031,0.00002225704,0.00003489163,0.00001708819,0.000007817696,0.00001472476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002818592,0.000003728557,0.0001956244,0.00001059992,9.83879e-7,0.00001873253,0.000007190676,0.000009730868,0.9995114,0.00001056042,0.000003867259,0.0001993765],"study_design_scores_gemma":[0.000008310108,0.0002102014,0.008341769,0.000001852178,0.000007501287,0.0002639007,0.00002514099,0.0004304321,0.9899874,0.00001251265,0.0007082094,0.000002689532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964037,0.0005727228,0.002319027,0.00004057196,0.000009767376,0.00001177254,0.0002139805,0.00003675456,0.0003917231],"genre_scores_gemma":[0.9964311,0.0002865005,0.00200964,0.00002289128,0.00000407657,0.00001750679,0.0003946497,0.000009254314,0.0008243771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006706055,"threshold_uncertainty_score":0.002219617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006872871539540377,"score_gpt":0.2233218300460667,"score_spread":0.2164489585065263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}