{"id":"W1985638339","doi":"10.1016/j.cca.2014.05.007","title":"Stable isotope dilution microquantification of creatine metabolites in plasma, whole blood and dried blood spots for pharmacological studies in mouse models of creatine deficiency","year":2014,"lang":"en","type":"article","venue":"Clinica Chimica Acta","topic":"Muscle metabolism and nutrition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Creatine; Spots; Dried blood; Whole blood; Chemistry; Isotope dilution; Blood plasma; Chromatography; Medicine; Internal medicine; Biochemistry; Mass spectrometry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007929778,0.0001578468,0.000494632,0.0001090313,0.00003850884,0.000007497353,0.0001579127,0.0001637212,0.00000405854],"category_scores_gemma":[0.0007792615,0.0001426479,0.00008273726,0.0001412957,0.0002070811,0.00001709488,0.00009065596,0.00008926477,1.680748e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003558048,"about_ca_system_score_gemma":0.00002987646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001389323,"about_ca_topic_score_gemma":0.00001958715,"domain_scores_codex":[0.9983762,0.000160431,0.0007478984,0.0004161104,0.00009074334,0.0002086401],"domain_scores_gemma":[0.9990029,0.0002223395,0.0003206031,0.0002504058,0.0001589142,0.00004485346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005483762,0.001210045,0.003895833,0.0001765653,0.00005439714,1.235296e-7,0.00009398392,0.00003436094,0.9933442,0.0002622097,0.00008903276,0.0002908808],"study_design_scores_gemma":[0.004951542,0.0004508664,0.01177454,0.00005586968,0.0002101714,0.000001685071,0.00008706276,0.001536818,0.9798029,0.0005185987,0.000453288,0.0001566545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970837,0.001836407,0.0001262117,0.0001260042,0.00005085659,0.0005171213,0.0001617054,0.000006646402,0.00009133044],"genre_scores_gemma":[0.9903486,0.005705661,0.003471127,0.00003814821,0.00006755426,0.00008544418,0.0002015353,0.00001438273,0.00006750218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01354129,"threshold_uncertainty_score":0.5817011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05284828983123218,"score_gpt":0.3293339126842376,"score_spread":0.2764856228530054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}