{"id":"W1985641799","doi":"10.1002/hep.21362","title":"Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver","year":2006,"lang":"en","type":"article","venue":"Hepatology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Université Laval","funders":"Canadian Institutes of Health Research; Université Laval","keywords":"Chenodeoxycholic acid; Glucuronidation; Chemistry; Farnesoid X receptor; Ursodeoxycholic acid; Enzyme; CYP8B1; Lithocholic acid; Bile acid; Cholestasis; Biochemistry; Activator (genetics); Cholesterol 7 alpha-hydroxylase; Glucuronosyltransferase; Sulfotransferase; Internal medicine; Nuclear receptor; Microsome; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001583476,0.0004310421,0.0003503297,0.0003242194,0.0001691386,0.000344466,0.00009949417,0.0002377116,0.0008520501],"category_scores_gemma":[0.0002106339,0.0001321913,0.0004740701,0.0003971135,0.0001719989,0.0001026382,0.0001342491,0.0002646357,0.0006667379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003760952,"about_ca_system_score_gemma":0.0002406605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002213554,"about_ca_topic_score_gemma":0.001600027,"domain_scores_codex":[0.9998313,0.00005323398,0.00001223379,0.00004585761,0.0000350353,0.00002226013],"domain_scores_gemma":[0.9999298,0.000009666104,0.00002027895,0.00001020282,0.00001624213,0.00001388362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005995751,0.0000252422,0.005661428,0.0001332455,0.00005985377,0.0002129987,0.00003908325,0.0002644029,0.9813449,0.0001956441,0.0002533417,0.01121025],"study_design_scores_gemma":[0.0000192585,0.0003356532,0.02856511,0.00001277227,0.00008623564,0.001322823,0.00003288658,0.001242928,0.9581726,0.0001121667,0.01008652,0.00001110713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9613692,0.02144476,0.01282832,0.0002960717,0.00008749542,0.00005584262,0.001475776,0.0003427038,0.002099864],"genre_scores_gemma":[0.9845887,0.004222468,0.004456707,0.00006083102,0.00001804323,0.0000271651,0.003325107,0.00002919147,0.003271851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002213554,"threshold_uncertainty_score":0.004401326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01479632668937727,"score_gpt":0.2524556627026023,"score_spread":0.237659336013225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}