{"id":"W1985661966","doi":"10.1016/j.jhep.2014.10.040","title":"Saikosaponin b2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry","year":2014,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":false,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University; Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research","keywords":"Hepatitis C virus; Virology; Viral entry; Virus; Viral life cycle; Entry inhibitor; Hepacivirus; Hepatitis C; Viral replication; Medicine; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007426402,0.0004298933,0.0002180455,0.0002430446,0.0001429002,0.0001832683,0.0001445718,0.0002267943,0.0009292389],"category_scores_gemma":[0.0000650348,0.0001089815,0.0002242055,0.0001677911,0.0001695722,0.0001753395,0.00016456,0.0005091465,0.0002836163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001173731,"about_ca_system_score_gemma":0.0002042246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002618188,"about_ca_topic_score_gemma":0.0004336259,"domain_scores_codex":[0.9999678,0.000006334278,0.000002658351,0.000005887064,0.000008645068,0.000008622081],"domain_scores_gemma":[0.9999559,0.000006934127,0.000007865268,0.000003640175,0.000004207189,0.00002150088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003665118,0.0000516964,0.000104516,0.00005952853,0.000007835693,0.00008289606,0.000004899161,0.0001277014,0.9955673,0.00005669055,0.00006105434,0.003509451],"study_design_scores_gemma":[0.000151276,0.001152338,0.001603914,0.000006046417,0.0000208285,0.0004495995,0.00001222796,0.000518242,0.9909621,0.00006790313,0.005048227,0.000007243062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841731,0.005828363,0.005000934,0.0001704974,0.00008815029,0.00009876367,0.0006735229,0.000127304,0.003839532],"genre_scores_gemma":[0.9908392,0.002355853,0.003515086,0.00007319225,0.0000265018,0.00005036723,0.0007818666,0.00001660662,0.002341312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009292389,"threshold_uncertainty_score":0.003108621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006912262017540392,"score_gpt":0.2255689988489656,"score_spread":0.2186567368314253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}